Table 1 Intrinsic dissociation rate... | American Society of Hematology

Table 1

Intrinsic dissociation rate constants (k⁰_off) and reactive compliance (σ) values for WT and mutant murine GPIbα–VWF-A1 tether bonds

Mouse rVWF–A1	k⁰_off (s⁻¹)	σ (nm)	R²
WT	3.05 ± 0.55	0.028 ± 0.001	0.97
R1326H	7.80 ± 1.15	0.039 ± 0.002	0.93
I1309V	0.49 ± 0.04	0.020 ± 0.003	0.95
I1309V, R1326H	4.15 ± 0.67	0.028 ± 0.001	0.94

Mouse rVWF–A1	k⁰_off (s⁻¹)	σ (nm)	R²
WT	3.05 ± 0.55	0.028 ± 0.001	0.97
R1326H	7.80 ± 1.15	0.039 ± 0.002	0.93
I1309V	0.49 ± 0.04	0.020 ± 0.003	0.95
I1309V, R1326H	4.15 ± 0.67	0.028 ± 0.001	0.94

Values were determined by using statistical MLE of Bell parameters.