Multivariate logistic regression for persistent end-of-induction MRD ≥0.01%
| Variable* . | Univariate analyses . | Multivariate model 1 . | Multivariate model 2 . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| OR . | 95% CI . | P . | OR . | 95% CI . | P . | OR . | 95% CI . | P . | |
| Age (y), continuous | 1.07 | 1.01-1.14 | .014 | ||||||
| Age at diagnosis (y) | .030 | ||||||||
| <13 | 1 | ||||||||
| ≥13 | 2.12 | 1.08-4.15 | |||||||
| NCI/Rome risk | .011 | ||||||||
| Standard | 1 | ||||||||
| High | 2.27 | 1.20-4.27 | |||||||
| WBC (per microliter), continuous | 1.01 | 1.00-1.01 | .052 | 1.91 | 1.10-3.33 | .021 | 1.91 | 1.10-3.34 | .021 |
| WBC, per microliter | .035 | ||||||||
| <50 000 | 1 | ||||||||
| ≥50 000 | 2.28 | 1.07-4.88 | |||||||
| Cytogenetics† | <.001 | .004 | .003 | ||||||
| Neutral | 1 | 1 | 1 | ||||||
| Favorable | 0.28 | 0.12-0.66 | 0.34 | 0.14-0.83 | 0.34 | 0.14-0.83 | |||
| Unfavorable | 4.05 | 0.71-22.94 | 5.25 | 0.89-31.84 | 5.59 | 0.91-34.32 | |||
| Obese | .013 | .016 | |||||||
| No | 1 | 1 | |||||||
| Yes | 2.51 | 1.23-5.16 | 2.57 | 1.19-5.54 | |||||
| Weight category | .042 | .046 | |||||||
| Lean | 1 | 1 | |||||||
| Overweight | 1.22 | 0.49-3.02 | 1.37 | 0.53-3.55 | |||||
| Obese | 2.62 | 1.24-5.50 | 2.74 | 1.24-6.10 | |||||
| Weight change during induction‡ | .016 | ||||||||
| Gain | 1 | ||||||||
| Loss | 2.17 | 1.15-4.08 | |||||||
| Variable* . | Univariate analyses . | Multivariate model 1 . | Multivariate model 2 . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| OR . | 95% CI . | P . | OR . | 95% CI . | P . | OR . | 95% CI . | P . | |
| Age (y), continuous | 1.07 | 1.01-1.14 | .014 | ||||||
| Age at diagnosis (y) | .030 | ||||||||
| <13 | 1 | ||||||||
| ≥13 | 2.12 | 1.08-4.15 | |||||||
| NCI/Rome risk | .011 | ||||||||
| Standard | 1 | ||||||||
| High | 2.27 | 1.20-4.27 | |||||||
| WBC (per microliter), continuous | 1.01 | 1.00-1.01 | .052 | 1.91 | 1.10-3.33 | .021 | 1.91 | 1.10-3.34 | .021 |
| WBC, per microliter | .035 | ||||||||
| <50 000 | 1 | ||||||||
| ≥50 000 | 2.28 | 1.07-4.88 | |||||||
| Cytogenetics† | <.001 | .004 | .003 | ||||||
| Neutral | 1 | 1 | 1 | ||||||
| Favorable | 0.28 | 0.12-0.66 | 0.34 | 0.14-0.83 | 0.34 | 0.14-0.83 | |||
| Unfavorable | 4.05 | 0.71-22.94 | 5.25 | 0.89-31.84 | 5.59 | 0.91-34.32 | |||
| Obese | .013 | .016 | |||||||
| No | 1 | 1 | |||||||
| Yes | 2.51 | 1.23-5.16 | 2.57 | 1.19-5.54 | |||||
| Weight category | .042 | .046 | |||||||
| Lean | 1 | 1 | |||||||
| Overweight | 1.22 | 0.49-3.02 | 1.37 | 0.53-3.55 | |||||
| Obese | 2.62 | 1.24-5.50 | 2.74 | 1.24-6.10 | |||||
| Weight change during induction‡ | .016 | ||||||||
| Gain | 1 | ||||||||
| Loss | 2.17 | 1.15-4.08 | |||||||
Only significant variables are depicted in the table. Gender, ethnicity, presence of trisomy 21, and presence of CNS disease were not significantly associated with persistent MRD in the bone marrow. See “Methods” for a description of multivariate model construction and retention of predictors.
A single patient with unknown cytogenetics was excluded from this analysis.
Weight change was also tested for an interaction with weight category and was not significant (P = .101 in model 1, and P = .157 in model 2).