TEAEs in ≥20% of all treated patients
| Preferred term . | 40-µg/kg dose (N = 18) . | All treated patients (N=131) . | ||
|---|---|---|---|---|
| All grades . | >Grade 3 . | All grades . | >Grade 3 . | |
| Any event | 100 | 100 | 100 | 96 |
| Febrile neutropenia | 72 | 72 | 57 | 57 |
| Fatigue | 56 | 11 | 49 | 10 |
| Thrombocytopenia | 50 | 25 | 44 | 40 |
| Anemia | 22 | 42 | 38 | 33 |
| Nausea | 39 | — | 34 | — |
| Diarrhea | 17 | — | 31 | 2 |
| Decreased appetite | 22 | 6 | 30 | 2 |
| Peripheral edema | 28 | — | 30 | 2 |
| Dyspnea | 44 | 6 | 29 | 7 |
| Constipation | 33 | — | 25 | — |
| Epistaxis | 22 | — | 24 | 2 |
| Hypokalemia | 11 | — | 24 | 5 |
| Cough | 28 | — | 22 | 1 |
| Chills | 33 | — | 21 | 1 |
| Contusion | 39 | — | 21 | — |
| Pyrexia | 17 | — | 20 | 1 |
| Neutropenia | 28 | 28 | 18 | 19 |
| Asthenia | 22 | 18 | 18 | — |
| Preferred term . | 40-µg/kg dose (N = 18) . | All treated patients (N=131) . | ||
|---|---|---|---|---|
| All grades . | >Grade 3 . | All grades . | >Grade 3 . | |
| Any event | 100 | 100 | 100 | 96 |
| Febrile neutropenia | 72 | 72 | 57 | 57 |
| Fatigue | 56 | 11 | 49 | 10 |
| Thrombocytopenia | 50 | 25 | 44 | 40 |
| Anemia | 22 | 42 | 38 | 33 |
| Nausea | 39 | — | 34 | — |
| Diarrhea | 17 | — | 31 | 2 |
| Decreased appetite | 22 | 6 | 30 | 2 |
| Peripheral edema | 28 | — | 30 | 2 |
| Dyspnea | 44 | 6 | 29 | 7 |
| Constipation | 33 | — | 25 | — |
| Epistaxis | 22 | — | 24 | 2 |
| Hypokalemia | 11 | — | 24 | 5 |
| Cough | 28 | — | 22 | 1 |
| Chills | 33 | — | 21 | 1 |
| Contusion | 39 | — | 21 | — |
| Pyrexia | 17 | — | 20 | 1 |
| Neutropenia | 28 | 28 | 18 | 19 |
| Asthenia | 22 | 18 | 18 | — |
Dashes indicate that toxicity did not occur at higher than Grade 3.