FcγR-profiles of children treated with IUT because of severe HDFN compared with healthy controls
| . | Controls (N = 199) (%) . | IUT Children (N = 72) (%) . |
|---|---|---|
| FCGR2A | ||
| Allele frequency | ||
| 131H* | 214 (53.5) | 77 (53.5) |
| 131R | 186 (46.5) | 67 (46.5) |
| Phenotype frequency | ||
| At least 1 131H | 155 (77.9) | 56 (77.8) |
| No 131H | 44 (22.1) | 16 (22.2) |
| FCGR2B | ||
| Allele frequency | ||
| 232I† | 352 (88.4) | 129 (89.6) |
| 232T | 46 (11.6) | 15 (10.4) |
| 2B.1 GT | 727 (88.9) | 258 (86.6) |
| 2B.4 CA‡ | 49 (6.0) | 23 (7.7) |
| Phenotype frequency | ||
| 2B.4 | 39 (19.6) | 17 (23.6) |
| No 2B.4 | 160 (80.4) | 55 (76.4) |
| FCGR2C | ||
| Haplotype frequency | ||
| STOP | 363 (86.8) | 118 (76.6) |
| Classical-ORF§ | 44 (10.5) | 23 (14.9) |
| Nonclassical-ORF | 11 (2.6) | 13 (8.4) |
| Phenotype frequency | ||
| Classical ORF | 39 (19.6) | 23 (31.9)‖ |
| No Classical ORF | 160 (80.4) | 49 (68.1) |
| FCGR3A | ||
| Haplotype frequency | ||
| 158V | 135 (32.8) | 60 (41.1) |
| 158F | 276 (67.2) | 86 (58.9) |
| Phenotype frequency | ||
| At least 1 158V | 109 (54.8) | 51 (70.8)‖ |
| No 158V | 90 (45.2) | 21 (29.2) |
| FCGR3B | ||
| Allele frequency | ||
| FCGR3B*01¶ | 164 (39.9) | 58 (38.2) |
| FCGR3B*02 | 237 (57.7) | 87 (57.2) |
| FCGR3B*03¶ | 10 (2.4) | 7 (4.6) |
| Phenotype frequency | ||
| FCGR3B*01 | 127 (63.8) | 47 (66.2) |
| No FCGR3B*01 | 72 (36.2) | 24 (33.8) |
| . | Controls (N = 199) (%) . | IUT Children (N = 72) (%) . |
|---|---|---|
| FCGR2A | ||
| Allele frequency | ||
| 131H* | 214 (53.5) | 77 (53.5) |
| 131R | 186 (46.5) | 67 (46.5) |
| Phenotype frequency | ||
| At least 1 131H | 155 (77.9) | 56 (77.8) |
| No 131H | 44 (22.1) | 16 (22.2) |
| FCGR2B | ||
| Allele frequency | ||
| 232I† | 352 (88.4) | 129 (89.6) |
| 232T | 46 (11.6) | 15 (10.4) |
| 2B.1 GT | 727 (88.9) | 258 (86.6) |
| 2B.4 CA‡ | 49 (6.0) | 23 (7.7) |
| Phenotype frequency | ||
| 2B.4 | 39 (19.6) | 17 (23.6) |
| No 2B.4 | 160 (80.4) | 55 (76.4) |
| FCGR2C | ||
| Haplotype frequency | ||
| STOP | 363 (86.8) | 118 (76.6) |
| Classical-ORF§ | 44 (10.5) | 23 (14.9) |
| Nonclassical-ORF | 11 (2.6) | 13 (8.4) |
| Phenotype frequency | ||
| Classical ORF | 39 (19.6) | 23 (31.9)‖ |
| No Classical ORF | 160 (80.4) | 49 (68.1) |
| FCGR3A | ||
| Haplotype frequency | ||
| 158V | 135 (32.8) | 60 (41.1) |
| 158F | 276 (67.2) | 86 (58.9) |
| Phenotype frequency | ||
| At least 1 158V | 109 (54.8) | 51 (70.8)‖ |
| No 158V | 90 (45.2) | 21 (29.2) |
| FCGR3B | ||
| Allele frequency | ||
| FCGR3B*01¶ | 164 (39.9) | 58 (38.2) |
| FCGR3B*02 | 237 (57.7) | 87 (57.2) |
| FCGR3B*03¶ | 10 (2.4) | 7 (4.6) |
| Phenotype frequency | ||
| FCGR3B*01 | 127 (63.8) | 47 (66.2) |
| No FCGR3B*01 | 72 (36.2) | 24 (33.8) |