Classification of UA, ICUS-A, and pre-MDS conditions
| Condition . | UA . | ICUS-A . | CCUS . | IDUS . | CHIP . | MDS . | |
|---|---|---|---|---|---|---|---|
| Low risk . | High risk . | ||||||
| Cytopenia* | + | + | + | − | − | + | + |
| Dysplasia | nd | − | − | + | − | + | + |
| BM blasts, % | nd | <5% | <5% | <5% | <5% | <5% | >20% |
| Cytogenetic abnormalities | nd | −/+ | − | −/+ | +/− | + | ++ |
| Molecular aberrations | nd | − | + | − | + | + | +++ |
| Comment | Workup needed | Cytopenic patients | Noncytopenic patients | Classification of MDS is based on WHO definition | |||
| Condition . | UA . | ICUS-A . | CCUS . | IDUS . | CHIP . | MDS . | |
|---|---|---|---|---|---|---|---|
| Low risk . | High risk . | ||||||
| Cytopenia* | + | + | + | − | − | + | + |
| Dysplasia | nd | − | − | + | − | + | + |
| BM blasts, % | nd | <5% | <5% | <5% | <5% | <5% | >20% |
| Cytogenetic abnormalities | nd | −/+ | − | −/+ | +/− | + | ++ |
| Molecular aberrations | nd | − | + | − | + | + | +++ |
| Comment | Workup needed | Cytopenic patients | Noncytopenic patients | Classification of MDS is based on WHO definition | |||
“Unexplained anemia” (UA) is the term used in the literature so far. In these patients, a thorough workup including BM and molecular analyses is recommended. These investigations will enable classification of the diagnosis ICUS-A, CCUS, or MDS or will help exclude other malignant hematologic disorders. Based on Valent et al.7
IDUS, idiopathic dysplasia of undetermined significance; nd, not detected or not done.
The definition of anemia in cytopenia is based on WHO criteria: Hb <130 g/L in men and Hb <120 g/L in women.10