Toxicities occurring in more than 5% of the study population
| Adverse event . | Grade 1-2, n (%) . | Grade 3, n (%) . | Grade 4, n (%) . |
|---|---|---|---|
| Abdominal pain | 5 (19) | 1 (3) | 0 |
| Allergic rhinitis | 3 (10) | 0 | 0 |
| Anemia | 0 | 7 (29) | 0 |
| Anorexia | 7 (24) | 0 | 0 |
| Anxiety | 3 (10) | 0 | 0 |
| Back pain | 3 (10) | 0 | 0 |
| Constipation | 5 (19) | 0 | 0 |
| Cough | 6 (21) | 0 | 0 |
| Dehydration | 2 (7) | 1 (3) | 0 |
| Diarrhea | 7 (24) | 1 (3) | 0 |
| Dizziness | 2 (7) | 0 | 0 |
| Dysgeusia | 2 (7) | 0 | 0 |
| Dyspnea | 2 (7) | 0 | 0 |
| Edema | 4 (14) | 0 | 0 |
| Epistaxis | 3 (10) | 0 | 0 |
| Fatigue | 15 (52) | 0 | 0 |
| Febrile neutropenia | 0 | 2 (7) | 2 (7) |
| Fever | 7 (24) | 0 | 1 (3) |
| Gastroesophageal reflux disease | 2 (7) | 0 | 0 |
| Gastrointestinal disorders | 1 (3) | 1 (3) | 0 |
| Headache | 3 (10) | 0 | 0 |
| Hyponatremia | 0 | 2 (7) | 0 |
| Laryngitis | 2 (7) | 0 | 0 |
| Mucositis oral | 5 (19) | 4 (14) | 0 |
| Nasal congestion | 3 (10) | 0 | 0 |
| Nausea | 19 (66) | 0 | 0 |
| Neutropenia | 0 | 1 (3) | 1 (3) |
| Pain | 6 (21) | 0 | 0 |
| Pain in extremity | 2 (7) | 0 | 0 |
| Pneumonia | 0 | 1 (3) | 1 (3) |
| Pruritus | 2 (7) | 0 | 0 |
| Rash maculopapular | 2 (7) | 0 | 0 |
| Sepsis | 0 | 0 | 2 (7) |
| Sore throat | 2 (7) | 0 | 0 |
| Stomach pain | 2 (7) | 0 | 0 |
| Thrombocytopenia | 2 (7) | 4 (14) | 4 (14) |
| Upper respiratory infection | 2 (7) | 0 | 0 |
| Urinary tract infection | 2 (7) | 0 | 0 |
| Vomiting | 6 (21) | 1 (3) | 0 |
| Adverse event . | Grade 1-2, n (%) . | Grade 3, n (%) . | Grade 4, n (%) . |
|---|---|---|---|
| Abdominal pain | 5 (19) | 1 (3) | 0 |
| Allergic rhinitis | 3 (10) | 0 | 0 |
| Anemia | 0 | 7 (29) | 0 |
| Anorexia | 7 (24) | 0 | 0 |
| Anxiety | 3 (10) | 0 | 0 |
| Back pain | 3 (10) | 0 | 0 |
| Constipation | 5 (19) | 0 | 0 |
| Cough | 6 (21) | 0 | 0 |
| Dehydration | 2 (7) | 1 (3) | 0 |
| Diarrhea | 7 (24) | 1 (3) | 0 |
| Dizziness | 2 (7) | 0 | 0 |
| Dysgeusia | 2 (7) | 0 | 0 |
| Dyspnea | 2 (7) | 0 | 0 |
| Edema | 4 (14) | 0 | 0 |
| Epistaxis | 3 (10) | 0 | 0 |
| Fatigue | 15 (52) | 0 | 0 |
| Febrile neutropenia | 0 | 2 (7) | 2 (7) |
| Fever | 7 (24) | 0 | 1 (3) |
| Gastroesophageal reflux disease | 2 (7) | 0 | 0 |
| Gastrointestinal disorders | 1 (3) | 1 (3) | 0 |
| Headache | 3 (10) | 0 | 0 |
| Hyponatremia | 0 | 2 (7) | 0 |
| Laryngitis | 2 (7) | 0 | 0 |
| Mucositis oral | 5 (19) | 4 (14) | 0 |
| Nasal congestion | 3 (10) | 0 | 0 |
| Nausea | 19 (66) | 0 | 0 |
| Neutropenia | 0 | 1 (3) | 1 (3) |
| Pain | 6 (21) | 0 | 0 |
| Pain in extremity | 2 (7) | 0 | 0 |
| Pneumonia | 0 | 1 (3) | 1 (3) |
| Pruritus | 2 (7) | 0 | 0 |
| Rash maculopapular | 2 (7) | 0 | 0 |
| Sepsis | 0 | 0 | 2 (7) |
| Sore throat | 2 (7) | 0 | 0 |
| Stomach pain | 2 (7) | 0 | 0 |
| Thrombocytopenia | 2 (7) | 4 (14) | 4 (14) |
| Upper respiratory infection | 2 (7) | 0 | 0 |
| Urinary tract infection | 2 (7) | 0 | 0 |
| Vomiting | 6 (21) | 1 (3) | 0 |