Platelet-associated parasite killing (TUNEL+PF4+ iRBCs) between species and stages
| Patient cohort and Plasmodium species . | Samples analyzed, n . | Median number parasites counted per sample (IQR) . | Median % TUNEL+PF4+ iRBCs (IQR) . | P* . | P† . |
|---|---|---|---|---|---|
| Papua | |||||
| P falciparum | 50 | 54 (52-59) | 5.6 (1.8-11.3) | <.0001 | — |
| P vivax | 32 | 54 (51-58) | 59.3 (45.4-81.1) | Comparator | — |
| P malariae | 11 | 45 (39-50) | 14.3 (13.6-18.2) | .009 | — |
| Mixed infection | 6 | 59 (42-66) | 14.9 (7.8-51.5) | .150 | — |
| P vivax (ring) | 15 | 48 (28-61) | 6.4 (1.1-16.1) | — | Comparator |
| P vivax (mature) | 16 | 59 (44-88) | 63.6 (52.9-74.1) | — | <.0001 |
| P malariae (ring) | 6 | 12 (16-18) | 0 (0-3.5) | — | Comparator |
| P malariae (mature) | 9 | 40 (63-80) | 6.3 (4.4-8.8) | — | .007 |
| Sabah | |||||
| P falciparum | 14 | 95 (76-131) | 10.6 (5.4-14.6) | .043 | — |
| P vivax | 13 | 49 (21-104) | 16.7 (13.5-39.1) | Comparator | — |
| P knowlesi | 15 | 95 (78-101) | 14.2 (19.8-26.9) | .717 | — |
| P knowlesi (ring) | 8 | 96 (92-103) | 10.8 (8.0-24.3) | — | Comparator |
| P knowlesi (mature) | 5 | 78 (72-98) | 14.9 (8.6-51.5) | — | .354 |
| Patient cohort and Plasmodium species . | Samples analyzed, n . | Median number parasites counted per sample (IQR) . | Median % TUNEL+PF4+ iRBCs (IQR) . | P* . | P† . |
|---|---|---|---|---|---|
| Papua | |||||
| P falciparum | 50 | 54 (52-59) | 5.6 (1.8-11.3) | <.0001 | — |
| P vivax | 32 | 54 (51-58) | 59.3 (45.4-81.1) | Comparator | — |
| P malariae | 11 | 45 (39-50) | 14.3 (13.6-18.2) | .009 | — |
| Mixed infection | 6 | 59 (42-66) | 14.9 (7.8-51.5) | .150 | — |
| P vivax (ring) | 15 | 48 (28-61) | 6.4 (1.1-16.1) | — | Comparator |
| P vivax (mature) | 16 | 59 (44-88) | 63.6 (52.9-74.1) | — | <.0001 |
| P malariae (ring) | 6 | 12 (16-18) | 0 (0-3.5) | — | Comparator |
| P malariae (mature) | 9 | 40 (63-80) | 6.3 (4.4-8.8) | — | .007 |
| Sabah | |||||
| P falciparum | 14 | 95 (76-131) | 10.6 (5.4-14.6) | .043 | — |
| P vivax | 13 | 49 (21-104) | 16.7 (13.5-39.1) | Comparator | — |
| P knowlesi | 15 | 95 (78-101) | 14.2 (19.8-26.9) | .717 | — |
| P knowlesi (ring) | 8 | 96 (92-103) | 10.8 (8.0-24.3) | — | Comparator |
| P knowlesi (mature) | 5 | 78 (72-98) | 14.9 (8.6-51.5) | — | .354 |