Peripheral blood counts of indicated mouse genotypes
| Hematological parameters . | WT, n = 36 . | G6b+/hu, n = 37 . | G6bhu/hu, n = 37 . | G6bhu/−, n = 31 . | G6b−/−, n = 37 . | λ . | P . |
|---|---|---|---|---|---|---|---|
| Platelets, 109/L | 1118 ± 209 | 1127 ± 219 | 884 ± 214*** | 795 ± 187*** | 206 ± 86*** | 0.2 | 2 × 10−72 |
| Mean platelet volume, fL | 5.8 ± 0.2 | 5.8 ± 0.2 | 6.1 ± 0.5*** | 6.2 ± 0.4*** | 7.8 ± 0.4*** | −2 | 2 × 10−65 |
| Plateletcrit, % | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.1 ± 0 | — | — |
| Red blood cells, 1012/L | 11.1 ± 0.7 | 10.5 ± 0.7 | 10.7 ± 0.8 | 10.4 ± 0.6 | 10.0 ± 0.6 | — | — |
| Hematocrit, % | 33.6 ± 2.4 | 32.7 ± 1.8 | 33.1 ± 2.5 | 34.1 ± 1.9 | 31.8 ± 1.7 | — | — |
| White blood cells, 109/L | 7.5 ± 3.6 | 8.6 ± 2.3 | 7.4 ± 2.6 | 10.1 ± 6.1 | 13.1 ± 6.8*** | 0.5 | 8 × 10−7 |
| Lymphocytes, 109/L | 6.2 ± 2.7 | 7.4 ± 2.0 | 6.9 ± 2.2 | 7.8 ± 3.7 | 11.8 ± 4.9*** | 0.5 | 3 × 10−11 |
| Monocytes, 109/L | 0.5 ± 0.4 | 0.3 ± 0.2 | 0.5 ± 0.2 | 0.3 ± 0.3 | 0.5 ± 0.4 | — | — |
| Neutrophils, 109/L | 0.8 ± 0.4 | 0.9 ± 0.4 | 0.7 ± 0.3 | 1.2 ± 0.8 | 1.7 ± 1.1 | — | — |
| Eosinophils, 109/L | 0.1 ± 0.2 | 0 ± 0 | 0 ± 0 | 0 ± 0.1 | 0 ± 0 | — | — |
| Basophils, 109/L | 0.1 ± 0.3 | 0 ± 0 | 0.1 ± 0.2 | 0 ± 0.1 | 0.1 ± 0.1 | — | — |
| Hematological parameters . | WT, n = 36 . | G6b+/hu, n = 37 . | G6bhu/hu, n = 37 . | G6bhu/−, n = 31 . | G6b−/−, n = 37 . | λ . | P . |
|---|---|---|---|---|---|---|---|
| Platelets, 109/L | 1118 ± 209 | 1127 ± 219 | 884 ± 214*** | 795 ± 187*** | 206 ± 86*** | 0.2 | 2 × 10−72 |
| Mean platelet volume, fL | 5.8 ± 0.2 | 5.8 ± 0.2 | 6.1 ± 0.5*** | 6.2 ± 0.4*** | 7.8 ± 0.4*** | −2 | 2 × 10−65 |
| Plateletcrit, % | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.1 ± 0 | — | — |
| Red blood cells, 1012/L | 11.1 ± 0.7 | 10.5 ± 0.7 | 10.7 ± 0.8 | 10.4 ± 0.6 | 10.0 ± 0.6 | — | — |
| Hematocrit, % | 33.6 ± 2.4 | 32.7 ± 1.8 | 33.1 ± 2.5 | 34.1 ± 1.9 | 31.8 ± 1.7 | — | — |
| White blood cells, 109/L | 7.5 ± 3.6 | 8.6 ± 2.3 | 7.4 ± 2.6 | 10.1 ± 6.1 | 13.1 ± 6.8*** | 0.5 | 8 × 10−7 |
| Lymphocytes, 109/L | 6.2 ± 2.7 | 7.4 ± 2.0 | 6.9 ± 2.2 | 7.8 ± 3.7 | 11.8 ± 4.9*** | 0.5 | 3 × 10−11 |
| Monocytes, 109/L | 0.5 ± 0.4 | 0.3 ± 0.2 | 0.5 ± 0.2 | 0.3 ± 0.3 | 0.5 ± 0.4 | — | — |
| Neutrophils, 109/L | 0.8 ± 0.4 | 0.9 ± 0.4 | 0.7 ± 0.3 | 1.2 ± 0.8 | 1.7 ± 1.1 | — | — |
| Eosinophils, 109/L | 0.1 ± 0.2 | 0 ± 0 | 0 ± 0 | 0 ± 0.1 | 0 ± 0 | — | — |
| Basophils, 109/L | 0.1 ± 0.3 | 0 ± 0 | 0.1 ± 0.2 | 0 ± 0.1 | 0.1 ± 0.1 | — | — |
All values expressed as mean ± SD.
—, indicates that no statistical analysis was performed; λ, the coefficient for the power transformation to minimize heteroscedasticity and nonnormality; P, the result of a 1-way ANOVA on transformed data.
P < .001 compared with WT with the Dunnett post hoc test.