Response to splenectomy
| . | Response to splenectomy . | P* . | ||
|---|---|---|---|---|
| No response (Hb < 8 g/dL) (n = 31) . | Partial response (Hb 8 to <11 g/dL) (n = 110) . | Complete response (Hb ≥ 11) (n = 7) . | ||
| Presplenectomy hemoglobin <7 g/dL† | 9/16 (56%)‡ | 12/54‡ (22%) | 0/2‡ | .007 |
| Age at splenectomy, median (range) | 3.7 (0.6-37.8) n = 31 | 4.1 (0.4-32.2) n = 110 | 11.7 (1.6-18.6) n = 7 | .3 |
| Total bilirubin, mg/dL, median (range) | 4.6 (1.1-17.6) n = 27‡ | 3.7 (1.0-14.3) n = 92‡ | 2.0 (1.1-3.1) n = 6‡ | .005 |
| Absolute reticulocyte count (× 106 cells/μL), median (range) | 0.8 (0.1-6.5) n = 13‡ | 0.7 (0.2-5.4) n = 28‡ | 0.6 (0.5-0.6) n = 3‡ | .16 |
| Reticulocyte count (%) median (range) | 33.9 (2.5-61.3) n = 20‡ | 27.1 (4.3-69.3) n = 85‡ | 16.9 (13.6-30.5) n = 5‡ | .11 |
| Currently receiving regular transfusions | 6/30 (20%) | 13/108 (12%) | 0/6 (0%) | .15 |
| Amish | 0/31 (0%) | 50/110 (46%) | 1/7 (14%) | .001 |
| Genotype§ | ||||
| M/M | 9/31 (29%) | 34/58 (59%) | 6/6 (100%) | .0017 |
| M/N | 10/31 (32%) | 15/58 (26%) | 0/6 (0%) | .0005 |
| N/N | 12/31 (39%) | 9/58 (16%) | 0/6 (0%) | .5|| |
| . | Response to splenectomy . | P* . | ||
|---|---|---|---|---|
| No response (Hb < 8 g/dL) (n = 31) . | Partial response (Hb 8 to <11 g/dL) (n = 110) . | Complete response (Hb ≥ 11) (n = 7) . | ||
| Presplenectomy hemoglobin <7 g/dL† | 9/16 (56%)‡ | 12/54‡ (22%) | 0/2‡ | .007 |
| Age at splenectomy, median (range) | 3.7 (0.6-37.8) n = 31 | 4.1 (0.4-32.2) n = 110 | 11.7 (1.6-18.6) n = 7 | .3 |
| Total bilirubin, mg/dL, median (range) | 4.6 (1.1-17.6) n = 27‡ | 3.7 (1.0-14.3) n = 92‡ | 2.0 (1.1-3.1) n = 6‡ | .005 |
| Absolute reticulocyte count (× 106 cells/μL), median (range) | 0.8 (0.1-6.5) n = 13‡ | 0.7 (0.2-5.4) n = 28‡ | 0.6 (0.5-0.6) n = 3‡ | .16 |
| Reticulocyte count (%) median (range) | 33.9 (2.5-61.3) n = 20‡ | 27.1 (4.3-69.3) n = 85‡ | 16.9 (13.6-30.5) n = 5‡ | .11 |
| Currently receiving regular transfusions | 6/30 (20%) | 13/108 (12%) | 0/6 (0%) | .15 |
| Amish | 0/31 (0%) | 50/110 (46%) | 1/7 (14%) | .001 |
| Genotype§ | ||||
| M/M | 9/31 (29%) | 34/58 (59%) | 6/6 (100%) | .0017 |
| M/N | 10/31 (32%) | 15/58 (26%) | 0/6 (0%) | .0005 |
| N/N | 12/31 (39%) | 9/58 (16%) | 0/6 (0%) | .5|| |
The population for this table is 148 patients who were splenectomized and had known data for response to splenectomy.
Hb, hemoglobin.
P value from ordinal logistic regression model.
Median presplenectomy hemoglobin was 6.7 g/dL (range, 5-12.5 g/dL) for the no-response group, 7.5 g/dL (range, 4.5-13.5 g/dL) for the partial response group, and 8.5 g/dL (range, 7-10 g/dL) for the complete response group.
Data were available only for subsets of patients (some patients had unknown data).
Amish participants were excluded from the genotype categories.
In the ordinal logistic regression model of response to splenectomy, the NM/NM group was the reference group.