Transfusion status at the time of enrollment and hemolytic triggers
| . | Number of patients (n/N with known data) . | % . | Amish patients . | % . | Non-Amish patients . | % . |
|---|---|---|---|---|---|---|
| Transfusion status at enrollment* | ||||||
| Historically on regular transfusions† | 79/198 | 40 | 32/46 | 70 | 47/152 | 31 |
| Currently on regular transfusions‡ | 23§/198 | 12 | 0/46 | 0 | 23/152 | 15 |
| Intermittent transfusions only | 56/198 | 28 | 6/46 | 13 | 50/152 | 33 |
| Never transfused | 34/198 | 17 | 4/46 | 9 | 30/152 | 20 |
| Historical transfusions with unknown transfusion frequency | 6/198 | 3 | 4/46 | 9 | 2/152 | 1 |
| Hemolytic triggers | ||||||
| Presumed infections | 137/228|| | 60 | 41/53 | 30 | 96/175 | 70 |
| Stress | 59/207|| | 29 | 36/54 | 61 | 23/153 | 39 |
| Pregnancy | 20/39¶ | 51 | 13/41 | 33 | 26/89 | 67 |
| Transfused for an acute stressor | 127/247|| | 51 | 16/52 | 13 | 111/195 | 87 |
| Transfusions in the 12 mo prior to enrollment | ||||||
| Transfused at least once | 92/254 | 36 | 5/55 | 9 | 87/199 | 44 |
| Median hemoglobin (range) | 8.1 (5.5-11) | 8.8 (7.4-9) | 8 (5.5-11) | |||
| Not transfused | 162/254 | 64 | 50/55 | 91 | 112/199 | 56 |
| Median hemoglobin (range) | 9.6 (6.3-14.2) | 9.5 (8-11.2) | 9.6 (6.3-14.2) |
| . | Number of patients (n/N with known data) . | % . | Amish patients . | % . | Non-Amish patients . | % . |
|---|---|---|---|---|---|---|
| Transfusion status at enrollment* | ||||||
| Historically on regular transfusions† | 79/198 | 40 | 32/46 | 70 | 47/152 | 31 |
| Currently on regular transfusions‡ | 23§/198 | 12 | 0/46 | 0 | 23/152 | 15 |
| Intermittent transfusions only | 56/198 | 28 | 6/46 | 13 | 50/152 | 33 |
| Never transfused | 34/198 | 17 | 4/46 | 9 | 30/152 | 20 |
| Historical transfusions with unknown transfusion frequency | 6/198 | 3 | 4/46 | 9 | 2/152 | 1 |
| Hemolytic triggers | ||||||
| Presumed infections | 137/228|| | 60 | 41/53 | 30 | 96/175 | 70 |
| Stress | 59/207|| | 29 | 36/54 | 61 | 23/153 | 39 |
| Pregnancy | 20/39¶ | 51 | 13/41 | 33 | 26/89 | 67 |
| Transfused for an acute stressor | 127/247|| | 51 | 16/52 | 13 | 111/195 | 87 |
| Transfusions in the 12 mo prior to enrollment | ||||||
| Transfused at least once | 92/254 | 36 | 5/55 | 9 | 87/199 | 44 |
| Median hemoglobin (range) | 8.1 (5.5-11) | 8.8 (7.4-9) | 8 (5.5-11) | |||
| Not transfused | 162/254 | 64 | 50/55 | 91 | 112/199 | 56 |
| Median hemoglobin (range) | 9.6 (6.3-14.2) | 9.5 (8-11.2) | 9.6 (6.3-14.2) |
N, total number of patients with known data; n, number of patients.
The sample size is 202 because 53 children age 5 years and younger were not included in this analysis.
Historically received regular transfusions is defined as not receiving regular transfusions in the 12 months before enrollment and .6 transfusions per year before the 12-month period before enrollment.
Currently receiving regular transfusions is defined as receiving $6 transfusions over the last 12-month period before enrollment.
Twenty-three patients were receiving regular transfusions at the time of enrollment; 17 had had a splenectomy.
The denominators are less than 254 because some patients had unknown data for presumed infections, stress, or transfusion for an acute stressor.
Thirty-nine female patients had at least 1 pregnancy.