Effect of cohabitation status on overall survival in all 3243 patients with AML and in 1623 receiving intensive, overall and by age
| Cohabitation status . | Patients, n (%) . | HR* (95% CI) . | aHR† (95% CI) . | aHR†‡ (95% CI) . | aHR†§ (95% CI) . | aHR†‡§ (95% CI) . |
|---|---|---|---|---|---|---|
| All patients | ||||||
| Any age | ||||||
| Cohabitating | 2056 (63.4) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Living alone | 1187 (36.6) | 1.38 (1.29-1.50) | 1.21 (1.11-1.31) | 1.19 (1.10-1.30) | 1.20 (1.11-1.31) | 1.20 (1.10-1.31) |
| Age <60 y | ||||||
| Cohabitating | 622 (71.2) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Living alone | 251 (28.8) | 1.12 (0.94-1.35) | 1.18 (0.99-1.42) | 1.07 (0.89-1.29) | 1.13 (0.94-1.36) | 1.05 (0.87-1.27) |
| Age ≥60 y | ||||||
| Cohabitating | 1434 (53.7) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Living alone | 936 (39.5) | 1.38 (1.27-1.50) | 1.19 (1.08-1.30) | 1.20 (1.09-1.33) | 1.19 (1.08-1.30) | 1.21 (1.09-1.33) |
| Patients receiving intensive therapy | ||||||
| Any age | ||||||
| Cohabitating | 1182 (72.8) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Living alone | 441 (27.2) | 1.05 (0.93-1.20) | 1.09 (0.93-1.20) | 1.06 (0.93-1.21) | 1.11 (0.97-1.26) | 1.08 (0.95-1.24) |
| Age <60 y | ||||||
| Cohabitating | 588 (72.1) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Living alone | 228 (27.9) | 1.06 (0.88-1.29) | 1.12 (0.92-1.35) | 1.04 (0.86-1.29) | 1.07 (0.88-1.30) | 1.01 (0.82-1.23) |
| Age ≥60 y | ||||||
| Cohabitating | 594 (73.6) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Living alone | 213 (26.4) | 1.08 (0.91-1.28) | 1.08 (0.91-1.28) | 1.11 (0.92-1.32) | 1.13 (0.95-1.35) | 1.16 (0.96-1.39) |
| Cohabitation status . | Patients, n (%) . | HR* (95% CI) . | aHR† (95% CI) . | aHR†‡ (95% CI) . | aHR†§ (95% CI) . | aHR†‡§ (95% CI) . |
|---|---|---|---|---|---|---|
| All patients | ||||||
| Any age | ||||||
| Cohabitating | 2056 (63.4) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Living alone | 1187 (36.6) | 1.38 (1.29-1.50) | 1.21 (1.11-1.31) | 1.19 (1.10-1.30) | 1.20 (1.11-1.31) | 1.20 (1.10-1.31) |
| Age <60 y | ||||||
| Cohabitating | 622 (71.2) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Living alone | 251 (28.8) | 1.12 (0.94-1.35) | 1.18 (0.99-1.42) | 1.07 (0.89-1.29) | 1.13 (0.94-1.36) | 1.05 (0.87-1.27) |
| Age ≥60 y | ||||||
| Cohabitating | 1434 (53.7) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Living alone | 936 (39.5) | 1.38 (1.27-1.50) | 1.19 (1.08-1.30) | 1.20 (1.09-1.33) | 1.19 (1.08-1.30) | 1.21 (1.09-1.33) |
| Patients receiving intensive therapy | ||||||
| Any age | ||||||
| Cohabitating | 1182 (72.8) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Living alone | 441 (27.2) | 1.05 (0.93-1.20) | 1.09 (0.93-1.20) | 1.06 (0.93-1.21) | 1.11 (0.97-1.26) | 1.08 (0.95-1.24) |
| Age <60 y | ||||||
| Cohabitating | 588 (72.1) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Living alone | 228 (27.9) | 1.06 (0.88-1.29) | 1.12 (0.92-1.35) | 1.04 (0.86-1.29) | 1.07 (0.88-1.30) | 1.01 (0.82-1.23) |
| Age ≥60 y | ||||||
| Cohabitating | 594 (73.6) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Living alone | 213 (26.4) | 1.08 (0.91-1.28) | 1.08 (0.91-1.28) | 1.11 (0.92-1.32) | 1.13 (0.95-1.35) | 1.16 (0.96-1.39) |
Cox regression analysis.
Crude.
Adjusted for age and sex.
Adjusted for SES, including income, educational level, and occupation.
Adjusted for clinical factors, including white blood cell count, cytogenetic risk group, World Health Organization performance status, type of leukemia (de novo, secondary, or therapy-related AML), and comorbidity.