Agonists or treatments reported to metalloproteolytically release platelet membrane receptors
| . | Physiological agonist . | Experimental treatments . |
|---|---|---|
| GPIbα | Shear stress/VWF | Calmodulin inhibition |
| Oxidative stress | N-ethylmaleimide | |
| Mitochondria-aging reagents | ||
| BH3 mimetics | ||
| PMA | ||
| GPV | Thrombin | PMA |
| Calmodulin inhibition | ||
| Oxidative stress | N-ethylmaleimide | |
| Convulxin | ||
| GPVI | Collagen | Calmodulin inhibition |
| Fibrin | N-ethylmaleimide | |
| Shear stress | Mitochondrial-aging reagents | |
| Antiplatelet autoantibodies | BH3 mimetics | |
| Factor Xa | Convulxin | |
| Sema4D | Collagen | PMA |
| PAR-1 agonist | ||
| PKA activation | ||
| Calmodulin inhibition | ||
| CD40L | Collagen | PAR-1 agonist |
| Thrombin | PAR-4 agonist |
| . | Physiological agonist . | Experimental treatments . |
|---|---|---|
| GPIbα | Shear stress/VWF | Calmodulin inhibition |
| Oxidative stress | N-ethylmaleimide | |
| Mitochondria-aging reagents | ||
| BH3 mimetics | ||
| PMA | ||
| GPV | Thrombin | PMA |
| Calmodulin inhibition | ||
| Oxidative stress | N-ethylmaleimide | |
| Convulxin | ||
| GPVI | Collagen | Calmodulin inhibition |
| Fibrin | N-ethylmaleimide | |
| Shear stress | Mitochondrial-aging reagents | |
| Antiplatelet autoantibodies | BH3 mimetics | |
| Factor Xa | Convulxin | |
| Sema4D | Collagen | PMA |
| PAR-1 agonist | ||
| PKA activation | ||
| Calmodulin inhibition | ||
| CD40L | Collagen | PAR-1 agonist |
| Thrombin | PAR-4 agonist |
BH3, Bcl-2 homology domain 3; PAR, protease-activated receptor; PKA, protein kinase A.