Location of maximum linkage metrics defined by either an NPL score of 2.8 or higher or HLOD score of 1.8 or higher after the removal of high-LD SNP markers from analyses
| Chromosome . | Position, Mb . | NPL . | P . | HLOD . | Model . | P . |
|---|---|---|---|---|---|---|
| Affection status based on CLL and B-cell LPD, n = 206 families | ||||||
| ––––2q21.2 | 134.5 | 3.02 | .001 | 3.11 | Common recessive | 7.7×10−5 |
| ––––5q23.2 | 124.4 | 2.12 | .017 | 1.76 | Rare recessive | .004 |
| ––––6p22.1 | 29.1 | 2.81 | .003 | 2.22 | Common recessive | .001 |
| ––––11q12.1 | 59.5 | 1.79 | .037 | 1.95 | Rare recessive | .003 |
| ––––18q21.1 | 42.5 | 2.66 | .004 | 2.36 | Rare dominant | .001 |
| Affection status restricted to CLL, n = 182 families | ||||||
| ––––2q21.2 | 134.5 | 2.84 | .002 | 2.56 | Common recessive | 6.0×10−4 |
| ––––5q21.3 | 109.1 | 2.37 | .009 | 1.36 | Rare recessive | .013 |
| ––––6p22.1 | 29.1 | 2.44 | .007 | 1.63 | Common recessive | .006 |
| ––––11q12.1 | 58.4 | 1.54 | .062 | 1.71 | Rare recessive | .005 |
| ––––18q12.3 | 41.8 | 2.21 | .014 | 1.92 | Rare dominant | .029 |
| Chromosome . | Position, Mb . | NPL . | P . | HLOD . | Model . | P . |
|---|---|---|---|---|---|---|
| Affection status based on CLL and B-cell LPD, n = 206 families | ||||||
| ––––2q21.2 | 134.5 | 3.02 | .001 | 3.11 | Common recessive | 7.7×10−5 |
| ––––5q23.2 | 124.4 | 2.12 | .017 | 1.76 | Rare recessive | .004 |
| ––––6p22.1 | 29.1 | 2.81 | .003 | 2.22 | Common recessive | .001 |
| ––––11q12.1 | 59.5 | 1.79 | .037 | 1.95 | Rare recessive | .003 |
| ––––18q21.1 | 42.5 | 2.66 | .004 | 2.36 | Rare dominant | .001 |
| Affection status restricted to CLL, n = 182 families | ||||||
| ––––2q21.2 | 134.5 | 2.84 | .002 | 2.56 | Common recessive | 6.0×10−4 |
| ––––5q21.3 | 109.1 | 2.37 | .009 | 1.36 | Rare recessive | .013 |
| ––––6p22.1 | 29.1 | 2.44 | .007 | 1.63 | Common recessive | .006 |
| ––––11q12.1 | 58.4 | 1.54 | .062 | 1.71 | Rare recessive | .005 |
| ––––18q12.3 | 41.8 | 2.21 | .014 | 1.92 | Rare dominant | .029 |
α is the estimate of the proportion of families linked at a given genomic position.