Disease characteristics and induction response by CD33 expression quartile
| . | Q1 (n = 155) . | Q2 (n = 155) . | Q3 (n = 155) . | Q4 (n = 154) . | P . |
|---|---|---|---|---|---|
| Sex, n (%) | |||||
| Male | 83 (54%) | 83 (54%) | 79 (51%) | 86 (56%) | .864 |
| Female | 72 (46%) | 72 (46%) | 76 (49%) | 68 (44%) | |
| Median age, y (range) | 9.9 (0.02-23.9) | 11.4 (0.06-20.8) | 9.4 (0.2-22.8) | 11.1 (0.09-23.8) | .166 |
| Race, n (%) | |||||
| American Indian or Alaska Native | 3 (2%) | 0 (0%) | 1 (1%) | 0 (0%) | .085 |
| Asian | 7 (5%) | 8 (6%) | 6 (4%) | 12 (8%) | .549 |
| Hawaiian/Pacific Islander | 2 (2%) | 1 (1%) | 1 (1%) | 1 (1%) | .857 |
| Black | 13 (10%) | 18 (13%) | 22 (16%) | 21 (14%) | .555 |
| White | 106 (81%) | 112 (81%) | 111 (79%) | 113 (77%) | .826 |
| Unknown | 24 | 16 | 14 | 7 | |
| Ethnicity | |||||
| Hispanic or Latino | 36 (24%) | 28 (19%) | 22 (15%) | 17 (11%) | .016 |
| Not Hispanic or Latino | 111 (76%) | 117 (81%) | 129 (85%) | 134 (89%) | |
| Unknown | 8 | 10 | 4 | 3 | |
| Cytogenetics, n (%) | |||||
| Normal | 19 (13%) | 24 (17%) | 31 (21%) | 37 (25%) | .057 |
| t(8;21) | 46 (32%) | 29 (20%) | 12 (8%) | 4 (3%) | < .001 |
| inv(16) | 28 (19%) | 27 (19%) | 15 (10%) | 5 (3%) | < .001 |
| Abnormal 11 | 18 (12%) | 25 (18%) | 36 (24%) | 47 (32%) | < .001 |
| t(6;9)(p23;q34) | 2 (1%) | 1 (1%) | 8 (5%) | 5 (3%) | .058 |
| Monosomy 7 | 1 (1%) | 3 (2%) | 3 (2%) | 1 (1%) | .549 |
| Del(7q) | 5 (3%) | 3 (2%) | 3 (2%) | 3 (2%) | .83 |
| −5/5q− | 2 (1%) | 3 (2%) | 2 (1%) | 0 (0%) | .411 |
| 8 | 9 (6%) | 5 (4%) | 15 (10%) | 18 (12%) | .032 |
| Other | 16 (11%) | 22 (15%) | 22 (15%) | 29 (19%) | .246 |
| Unknown | 9 | 13 | 8 | 5 | |
| Mutations, n (%) | |||||
| FLT3/ITD | 13 (8%) | 15 (10%) | 30 (20%) | 33 (22%) | < .001 |
| CEBPA mutant | 9 (6%) | 11 (7%) | 10 (7%) | 5 (3%) | .499 |
| NPM mutant | 2 (1%) | 7 (5%) | 10 (7%) | 14 (10%) | .011 |
| Risk group, n (%) | |||||
| Standard | 53 (36%) | 57 (40%) | 82 (55%) | 104 (69%) | < .001 |
| Low | 82 (55%) | 74 (51%) | 43 (29%) | 25 (17%) | < .001 |
| High | 13 (9%) | 13 (9%) | 24 (16%) | 22 (15%) | .117 |
| Unknown | 7 | 11 | 6 | 3 | |
| Median WBCs, × 103 μL (range) | 21.9 (1.1-415.7) | 34.5 (1.3-526) | 36.2 (0.8-409) | 18.4 (0.8-447.3) | .003 |
| BM blasts, %, n (range) | 65.5 (2-100) | 70 (3-99) | 70 (5-100) | 71 (13-99) | .118 |
| Median platelets, 1000/μL (range) | 40.5 (2-468) | 41 (4-571) | 55.5 (4-578) | 63.5 (1-524) | .007 |
| Median hemoglobin, g/dL (range) | 8.1 (2.8-15.2) | 8 (3.3-17) | 8.2 (2.3-14.9) | 8.4 (3.1-15.3) | .289 |
| . | Q1 (n = 155) . | Q2 (n = 155) . | Q3 (n = 155) . | Q4 (n = 154) . | P . |
|---|---|---|---|---|---|
| Sex, n (%) | |||||
| Male | 83 (54%) | 83 (54%) | 79 (51%) | 86 (56%) | .864 |
| Female | 72 (46%) | 72 (46%) | 76 (49%) | 68 (44%) | |
| Median age, y (range) | 9.9 (0.02-23.9) | 11.4 (0.06-20.8) | 9.4 (0.2-22.8) | 11.1 (0.09-23.8) | .166 |
| Race, n (%) | |||||
| American Indian or Alaska Native | 3 (2%) | 0 (0%) | 1 (1%) | 0 (0%) | .085 |
| Asian | 7 (5%) | 8 (6%) | 6 (4%) | 12 (8%) | .549 |
| Hawaiian/Pacific Islander | 2 (2%) | 1 (1%) | 1 (1%) | 1 (1%) | .857 |
| Black | 13 (10%) | 18 (13%) | 22 (16%) | 21 (14%) | .555 |
| White | 106 (81%) | 112 (81%) | 111 (79%) | 113 (77%) | .826 |
| Unknown | 24 | 16 | 14 | 7 | |
| Ethnicity | |||||
| Hispanic or Latino | 36 (24%) | 28 (19%) | 22 (15%) | 17 (11%) | .016 |
| Not Hispanic or Latino | 111 (76%) | 117 (81%) | 129 (85%) | 134 (89%) | |
| Unknown | 8 | 10 | 4 | 3 | |
| Cytogenetics, n (%) | |||||
| Normal | 19 (13%) | 24 (17%) | 31 (21%) | 37 (25%) | .057 |
| t(8;21) | 46 (32%) | 29 (20%) | 12 (8%) | 4 (3%) | < .001 |
| inv(16) | 28 (19%) | 27 (19%) | 15 (10%) | 5 (3%) | < .001 |
| Abnormal 11 | 18 (12%) | 25 (18%) | 36 (24%) | 47 (32%) | < .001 |
| t(6;9)(p23;q34) | 2 (1%) | 1 (1%) | 8 (5%) | 5 (3%) | .058 |
| Monosomy 7 | 1 (1%) | 3 (2%) | 3 (2%) | 1 (1%) | .549 |
| Del(7q) | 5 (3%) | 3 (2%) | 3 (2%) | 3 (2%) | .83 |
| −5/5q− | 2 (1%) | 3 (2%) | 2 (1%) | 0 (0%) | .411 |
| 8 | 9 (6%) | 5 (4%) | 15 (10%) | 18 (12%) | .032 |
| Other | 16 (11%) | 22 (15%) | 22 (15%) | 29 (19%) | .246 |
| Unknown | 9 | 13 | 8 | 5 | |
| Mutations, n (%) | |||||
| FLT3/ITD | 13 (8%) | 15 (10%) | 30 (20%) | 33 (22%) | < .001 |
| CEBPA mutant | 9 (6%) | 11 (7%) | 10 (7%) | 5 (3%) | .499 |
| NPM mutant | 2 (1%) | 7 (5%) | 10 (7%) | 14 (10%) | .011 |
| Risk group, n (%) | |||||
| Standard | 53 (36%) | 57 (40%) | 82 (55%) | 104 (69%) | < .001 |
| Low | 82 (55%) | 74 (51%) | 43 (29%) | 25 (17%) | < .001 |
| High | 13 (9%) | 13 (9%) | 24 (16%) | 22 (15%) | .117 |
| Unknown | 7 | 11 | 6 | 3 | |
| Median WBCs, × 103 μL (range) | 21.9 (1.1-415.7) | 34.5 (1.3-526) | 36.2 (0.8-409) | 18.4 (0.8-447.3) | .003 |
| BM blasts, %, n (range) | 65.5 (2-100) | 70 (3-99) | 70 (5-100) | 71 (13-99) | .118 |
| Median platelets, 1000/μL (range) | 40.5 (2-468) | 41 (4-571) | 55.5 (4-578) | 63.5 (1-524) | .007 |
| Median hemoglobin, g/dL (range) | 8.1 (2.8-15.2) | 8 (3.3-17) | 8.2 (2.3-14.9) | 8.4 (3.1-15.3) | .289 |