Pretransplant and transplant characteristics of the 21 patients with cardiovascular disease after HSCT, and type of arterial vascular events
| UPN . | Age at HSCT, y . | Sex . | Disease . | TBI . | Acute GvHD . | Chron GvHD . | Status . | Age at first event, y . | Time interval, y . | Stop IS*, y . | Type of cardiovascular event/cause of death . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Patients with a cerebrovascular event | |||||||||||
| 074 | 31 | F | AML | sTBI | 2 | Mod. | Alive | 52 | 20.7 | 20 | Transient ischemic attack |
| 080 | 40 | F | AML | sTBI | 0 | Mod. | Alive | 61 | 20.8 | 17 | Cerebrovascular arteriosclerosis and dementia |
| 097 | 36 | F | CML | sTBI | 2 | Mod. | Alive | 48 | 12.6 | 11 | Stroke |
| 174 | 19 | F | AML | sTBI | 0 | None | Dead | 29 | 16 | 10 | Stroke |
| 312 | 43 | M | AML | fTBI | 0 | None | Alive | 59 | 15.7 | 12 | Transient ischemic attack |
| 442 | 44 | M | CML | fTBI | 1 | None | Dead | 50 | 5.8 | 5 | Transient ischemic attack/relapse |
| 562 | 35 | F | AML | fTBI | 1 | None | Alive | 43 | 8.5 | On | Stroke |
| 832 | 44 | M | AML | fTBI | 0 | None | Dead | 46 | 2.3 | On | Lacunar infarcts/relapse |
| Patients with a coronary artery event | |||||||||||
| 192 | 19 | M | AML | fTBI | 2 | Mod. | Alive | 38 | 19.2 | 15 | Myocardial infarction |
| 326 | 41 | M | CML | fTBI | 2 | None | Alive | 58 | 16.2 | 13 | Angina pectoris |
| 394 | 44 | M | MDS | fTBI | 1 | None | Alive | 57 | 13.6 | 13 | Myocardial infarction |
| 433 | 29 | M | CML | fTBI | 2 | None | Alive | 42 | 13.3 | 10 | Angina pectoris, atrial fibrillation |
| 517 | 47 | M | AML | fTBI | 1 | None | Alive | 53 | 6.9 | 5 | Angina pectoris necessitating coronary bypass |
| 648 | 33 | M | CML | fTBI | 0 | None | Alive | 40 | 6.4 | 5 | Angina pectoris |
| 684 | 52 | M | MPS | fTBI | 2 | Mod. | Dead | 55 | 2 | On | Chronic coronary disease/relapse |
| Patients with cardiovascular events in more than one territory | |||||||||||
| 418 | 28 | M | CML | fTBI | 2 | Severe | Dead | 31 | 2.3 | On | Transient ischemic attack, angina pectoris, arterial occlusive disease, amputation. Cause of death: myocardial infarction |
| 557 | 38 | M | MDS | fTBI | 2 | Mod. | Alive | 46 | 7.6 | On | Stroke, chronic coronary disease, arterial occlusive disease, amputation |
| 770 | 59 | M | MDS | No TBI | 1 | None | Dead | 62 | 3.0 | On | Chronic coronary disease, arteriosclerosis. Cause of death: relapse |
| Patients treated with autologous HSCT with cardiovascular events | |||||||||||
| 390 | 36 | M | Hodgkin | No | NA | NA | Alive | 38 | 1.3 | NA | Chronic coronary disease |
| 670 | 50 | M | Myeloma | No | NA | NA | Alive | 63 | 3.7 | NA | Stroke |
| 695 | 59 | F | Myeloma | No | NA | NA | Dead | 69 | 0.74 | NA | Stroke |
| UPN . | Age at HSCT, y . | Sex . | Disease . | TBI . | Acute GvHD . | Chron GvHD . | Status . | Age at first event, y . | Time interval, y . | Stop IS*, y . | Type of cardiovascular event/cause of death . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Patients with a cerebrovascular event | |||||||||||
| 074 | 31 | F | AML | sTBI | 2 | Mod. | Alive | 52 | 20.7 | 20 | Transient ischemic attack |
| 080 | 40 | F | AML | sTBI | 0 | Mod. | Alive | 61 | 20.8 | 17 | Cerebrovascular arteriosclerosis and dementia |
| 097 | 36 | F | CML | sTBI | 2 | Mod. | Alive | 48 | 12.6 | 11 | Stroke |
| 174 | 19 | F | AML | sTBI | 0 | None | Dead | 29 | 16 | 10 | Stroke |
| 312 | 43 | M | AML | fTBI | 0 | None | Alive | 59 | 15.7 | 12 | Transient ischemic attack |
| 442 | 44 | M | CML | fTBI | 1 | None | Dead | 50 | 5.8 | 5 | Transient ischemic attack/relapse |
| 562 | 35 | F | AML | fTBI | 1 | None | Alive | 43 | 8.5 | On | Stroke |
| 832 | 44 | M | AML | fTBI | 0 | None | Dead | 46 | 2.3 | On | Lacunar infarcts/relapse |
| Patients with a coronary artery event | |||||||||||
| 192 | 19 | M | AML | fTBI | 2 | Mod. | Alive | 38 | 19.2 | 15 | Myocardial infarction |
| 326 | 41 | M | CML | fTBI | 2 | None | Alive | 58 | 16.2 | 13 | Angina pectoris |
| 394 | 44 | M | MDS | fTBI | 1 | None | Alive | 57 | 13.6 | 13 | Myocardial infarction |
| 433 | 29 | M | CML | fTBI | 2 | None | Alive | 42 | 13.3 | 10 | Angina pectoris, atrial fibrillation |
| 517 | 47 | M | AML | fTBI | 1 | None | Alive | 53 | 6.9 | 5 | Angina pectoris necessitating coronary bypass |
| 648 | 33 | M | CML | fTBI | 0 | None | Alive | 40 | 6.4 | 5 | Angina pectoris |
| 684 | 52 | M | MPS | fTBI | 2 | Mod. | Dead | 55 | 2 | On | Chronic coronary disease/relapse |
| Patients with cardiovascular events in more than one territory | |||||||||||
| 418 | 28 | M | CML | fTBI | 2 | Severe | Dead | 31 | 2.3 | On | Transient ischemic attack, angina pectoris, arterial occlusive disease, amputation. Cause of death: myocardial infarction |
| 557 | 38 | M | MDS | fTBI | 2 | Mod. | Alive | 46 | 7.6 | On | Stroke, chronic coronary disease, arterial occlusive disease, amputation |
| 770 | 59 | M | MDS | No TBI | 1 | None | Dead | 62 | 3.0 | On | Chronic coronary disease, arteriosclerosis. Cause of death: relapse |
| Patients treated with autologous HSCT with cardiovascular events | |||||||||||
| 390 | 36 | M | Hodgkin | No | NA | NA | Alive | 38 | 1.3 | NA | Chronic coronary disease |
| 670 | 50 | M | Myeloma | No | NA | NA | Alive | 63 | 3.7 | NA | Stroke |
| 695 | 59 | F | Myeloma | No | NA | NA | Dead | 69 | 0.74 | NA | Stroke |
TBI indicates total body irradiation; s, single dose; f, fractionated dose; Mod., moderate; NA, not applicable; On, on immunosuppression at time of first event.
Stop IS, time interval in years between stop of immunosuppression and first arterial event.