Frequency of KIR transcript detection
| . | KIR Transcript Frequency . | KIR Genotype C (Toneva et al25 ) . | ||
|---|---|---|---|---|
| HIV+ . | EUs . | C . | ||
| KIR2DS1 | 27 | 52 | 48 | 50 (37) |
| KIR2DS2 | 39 | 36 | 48 | 50 (41) |
| KIR2DS3 | 0 | 8 | 24 | 58 (31) |
| Expressed KIR2DS4 | 77* | 60 | 67 | NT (NT) |
| KIR2DS5 | 47 | 28 | 33 | 42 (NT) |
| KIR2DL1 | 73 | 92 | 100 | 100 (98) |
| KIR2DL2 | 33 | 40 | 52 | 50 (45) |
| KIR2DL3 | 76* | 100 | 95 | 92 (66) |
| KIR2DL4 | 88 | 100 | 100 | 100 (NT) |
| KIR2DL5 | 22 | 40 | 52 | 50 (NT) |
| KIR3DS1 | 18 | 48 | 43 | 50 (41) |
| KIR3DL1 | 35† | 76 | 86 | 92 (88) |
| KIR3DL2 | 94 | 100 | 100 | 100 (100) |
| KIR3DL3 | 78 | 60 | 71 | 100 (NT) |
| 2DL3+2DS2−2DL2− | 47 | 60 | 38 | NT (NT) |
| 2DL3+2DS2+/−2DL2+/− | 53 | 40 | 62 | NT (NT) |
| . | KIR Transcript Frequency . | KIR Genotype C (Toneva et al25 ) . | ||
|---|---|---|---|---|
| HIV+ . | EUs . | C . | ||
| KIR2DS1 | 27 | 52 | 48 | 50 (37) |
| KIR2DS2 | 39 | 36 | 48 | 50 (41) |
| KIR2DS3 | 0 | 8 | 24 | 58 (31) |
| Expressed KIR2DS4 | 77* | 60 | 67 | NT (NT) |
| KIR2DS5 | 47 | 28 | 33 | 42 (NT) |
| KIR2DL1 | 73 | 92 | 100 | 100 (98) |
| KIR2DL2 | 33 | 40 | 52 | 50 (45) |
| KIR2DL3 | 76* | 100 | 95 | 92 (66) |
| KIR2DL4 | 88 | 100 | 100 | 100 (NT) |
| KIR2DL5 | 22 | 40 | 52 | 50 (NT) |
| KIR3DS1 | 18 | 48 | 43 | 50 (41) |
| KIR3DL1 | 35† | 76 | 86 | 92 (88) |
| KIR3DL2 | 94 | 100 | 100 | 100 (100) |
| KIR3DL3 | 78 | 60 | 71 | 100 (NT) |
| 2DL3+2DS2−2DL2− | 47 | 60 | 38 | NT (NT) |
| 2DL3+2DS2+/−2DL2+/− | 53 | 40 | 62 | NT (NT) |
The frequency of KIR transcript detection was analyzed in 17 HIV-infected individuals (HIV), 25 EUs, and 21 unexposed controls (C) (and compared to genomic KIR frequencies reported by Toneva et al25 in 59 Vietnamese subjects [in parentheses]). HIV+ individuals show lower KIR transcript frequencies for KIR3DS1 (P < .10) and KIR3DL1 (P < .001). Genomic analysis confirmed the weak KIR3DS1 frequency in HIV+ (18%). Dissociation between KIR3DL1 gene and transcript detection was detected in 3 (21.4%) of 14 EUs tested and 3 (37.5%) of 8 HIV+ individuals, but was never observed in tested controls (n = 12). Expressed KIR2DS4 transcript frequencies refer to transcription alleles encoding the expressed KIR2DS4 receptor (exclusive of individuals only expressing the KIR1D null allele).
Italics in the data field indicate statistical trends (P < .1).
P < .05.
P < .001.