Hematologic response criteria
| Major hematologic response (MaHR) |
| Complete hematologic response (CHR) |
| White blood cell (WBC) count no more than institutional ULN |
| Absolute neutrophil count (ANC) ≥ 1 × 109/L (1000/mm3) |
| Platelet count ≥ 100 × 109/L (100 000/mm3) |
| No blasts or promyelocytes in peripheral blood |
| Bone marrow blasts ≤ 5% |
| Less than 5% myelocytes plus metamyelocytes in peripheral blood |
| Basophils in peripheral blood < 2% and basophils in the bone marrow < 2% |
| No extramedullary involvement (including no hepatomegaly or splenomegaly) |
| No evidence of leukemia (NEL) |
| WBC count no more than institutional ULN |
| No blasts or promyelocytes in peripheral blood |
| Bone marrow blasts ≤ 5% |
| Less than 5% myelocytes plus metamyelocytes in peripheral blood |
| No extramedullary involvement (including no hepatomegaly or splenomegaly) |
| Basophils in peripheral blood < 2% and at least one of the following: |
| 20 × 109/L (20 000/mm3) ≤ platelets < 100 × 109/L (100 000/mm3) |
| 0.5 × 109/L (500/mm3) ≤ ANC < 1.0 × 109/L (1000/mm3) |
| Minor hematologic response (MiHR) |
| Less than 15% blasts in bone marrow and in peripheral blood |
| Less than 30% blasts plus promyelocytes in bone marrow and < 30% blasts plus promyelocytes in peripheral blood |
| Less than 2% basophils in peripheral blood |
| No extramedullary involvement other than spleen and liver |
| Major hematologic response (MaHR) |
| Complete hematologic response (CHR) |
| White blood cell (WBC) count no more than institutional ULN |
| Absolute neutrophil count (ANC) ≥ 1 × 109/L (1000/mm3) |
| Platelet count ≥ 100 × 109/L (100 000/mm3) |
| No blasts or promyelocytes in peripheral blood |
| Bone marrow blasts ≤ 5% |
| Less than 5% myelocytes plus metamyelocytes in peripheral blood |
| Basophils in peripheral blood < 2% and basophils in the bone marrow < 2% |
| No extramedullary involvement (including no hepatomegaly or splenomegaly) |
| No evidence of leukemia (NEL) |
| WBC count no more than institutional ULN |
| No blasts or promyelocytes in peripheral blood |
| Bone marrow blasts ≤ 5% |
| Less than 5% myelocytes plus metamyelocytes in peripheral blood |
| No extramedullary involvement (including no hepatomegaly or splenomegaly) |
| Basophils in peripheral blood < 2% and at least one of the following: |
| 20 × 109/L (20 000/mm3) ≤ platelets < 100 × 109/L (100 000/mm3) |
| 0.5 × 109/L (500/mm3) ≤ ANC < 1.0 × 109/L (1000/mm3) |
| Minor hematologic response (MiHR) |
| Less than 15% blasts in bone marrow and in peripheral blood |
| Less than 30% blasts plus promyelocytes in bone marrow and < 30% blasts plus promyelocytes in peripheral blood |
| Less than 2% basophils in peripheral blood |
| No extramedullary involvement other than spleen and liver |