Somatic hypermutation in B-cell subpopulations
| Name . | Average SHM/sequence . | R/S ratio . |
|---|---|---|
| Naive*† | 0.7 | 1.8 |
| Naive without marginal zone and pro-GC cells†‡ | 0.4 | 1 |
| Pro-GC | 1.0 | 1.9 |
| Pre-GC‡ | 3.9 | 1.9 |
| Germinal center‡ | 14.7 | 3.9 |
| Memory‡ | 14.3 | 1.8 |
| Name . | Average SHM/sequence . | R/S ratio . |
|---|---|---|
| Naive*† | 0.7 | 1.8 |
| Naive without marginal zone and pro-GC cells†‡ | 0.4 | 1 |
| Pro-GC | 1.0 | 1.9 |
| Pre-GC‡ | 3.9 | 1.9 |
| Germinal center‡ | 14.7 | 3.9 |
| Memory‡ | 14.3 | 1.8 |
Here, naive cells represent a population contaminated by marginal zone T-independent B cells (IgM+IgD+CD27+CD38−) and pro-GC cells artificially increasing the mutation rate and R/S ratio.
Top 10% of mutated cells representing marginal zone and pro-GC cells have been removed.
‡Sequences from Zheng et al.3