Comparison of measures of anticoagulation control prior to and during the intervention period between the vitamin K- and placebo-treated groups of patients
| Variable . | Vitamin K group . | Placebo group . | ||||
|---|---|---|---|---|---|---|
| Before study . | Intervention period . | Difference . | Before study . | Intervention period . | Difference . | |
| SD of INR | 0.72 ± 0.11 | 0.47 ± 0.17 | −0.24 ± 0.14* | 0.7 ± 0.11 | 0.59 ± 0.15 | −0.11 ± 0.18* |
| Time in range, % | 59 ± 20 | 87 ± 14 | 28 ± 20† | 63 ± 18 | 78 ± 17 | 15 ± 20† |
| No. of dose changes, median (range) | 5 (3-7) | 2 (0-5) | −2 (−5-0)* | 5 (3-8) | 3 (1-8) | −1 (−3-3)* |
| Variable . | Vitamin K group . | Placebo group . | ||||
|---|---|---|---|---|---|---|
| Before study . | Intervention period . | Difference . | Before study . | Intervention period . | Difference . | |
| SD of INR | 0.72 ± 0.11 | 0.47 ± 0.17 | −0.24 ± 0.14* | 0.7 ± 0.11 | 0.59 ± 0.15 | −0.11 ± 0.18* |
| Time in range, % | 59 ± 20 | 87 ± 14 | 28 ± 20† | 63 ± 18 | 78 ± 17 | 15 ± 20† |
| No. of dose changes, median (range) | 5 (3-7) | 2 (0-5) | −2 (−5-0)* | 5 (3-8) | 3 (1-8) | −1 (−3-3)* |
For the vitamin K group, n = 35; for the placebo group, n = 33.
*Significant difference (P < .001).
†Significant difference (P < .01).