Standardized incidence ratios of specific cardiac diseases in 5-year survivors of Hodgkin lymphoma
| Diagnosis . | ICD-9 codes . | O . | E . | SIR . | 95% CI . | AER* . | Median interval, y (range) . |
|---|---|---|---|---|---|---|---|
| Combined diagnostic group | |||||||
| Coronary heart disease† | 410, 413 | 233 | 57.7 | 4.0 | 3.5-4.6 | 87.0 | 20.2 (5.0-37.2) |
| Coronary heart disease‡ | 410, 413 | 182 | 57.7 | 3.2 | 2.7-3.7 | 61.7 | 20.2 (5.0-37.2) |
| Specific heart diseases | |||||||
| Acute myocardial infarction | 410 | 102§ | 28.5 | 3.6 | 2.9-4.4 | 35.7 | 19.5 (7.0-37.5) |
| Angina pectoris | 413 | 134‖ | 32.4 | 4.1 | 3.5-4.9 | 49.6 | 20.7 (5.1-37.2) |
| Congestive heart failure | 428 | 52¶ | 10.7 | 4.9 | 3.6-6.4 | 25.6 | 18.5 (5.0-39.0) |
| Pericarditis# | 420, 423 | 23 | — | — | — | — | 13.6 (6.4-31.1) |
| Valvular disorders# | 424 | 160 | — | — | — | — | 23.3 (5.0-37.8) |
| Cardiomyopathy# | 425 | 33 | — | — | — | — | 18.0 (5.8-34.0) |
| Dysrhythmia# | 427 | 89 | — | — | — | — | 18.3 (5.2-39.6) |
| All heart diseases# | 410-429 | 619** | — | — | — | — | 18.8 (5.0-39.6) |
| Diagnosis . | ICD-9 codes . | O . | E . | SIR . | 95% CI . | AER* . | Median interval, y (range) . |
|---|---|---|---|---|---|---|---|
| Combined diagnostic group | |||||||
| Coronary heart disease† | 410, 413 | 233 | 57.7 | 4.0 | 3.5-4.6 | 87.0 | 20.2 (5.0-37.2) |
| Coronary heart disease‡ | 410, 413 | 182 | 57.7 | 3.2 | 2.7-3.7 | 61.7 | 20.2 (5.0-37.2) |
| Specific heart diseases | |||||||
| Acute myocardial infarction | 410 | 102§ | 28.5 | 3.6 | 2.9-4.4 | 35.7 | 19.5 (7.0-37.5) |
| Angina pectoris | 413 | 134‖ | 32.4 | 4.1 | 3.5-4.9 | 49.6 | 20.7 (5.1-37.2) |
| Congestive heart failure | 428 | 52¶ | 10.7 | 4.9 | 3.6-6.4 | 25.6 | 18.5 (5.0-39.0) |
| Pericarditis# | 420, 423 | 23 | — | — | — | — | 13.6 (6.4-31.1) |
| Valvular disorders# | 424 | 160 | — | — | — | — | 23.3 (5.0-37.8) |
| Cardiomyopathy# | 425 | 33 | — | — | — | — | 18.0 (5.8-34.0) |
| Dysrhythmia# | 427 | 89 | — | — | — | — | 18.3 (5.2-39.6) |
| All heart diseases# | 410-429 | 619** | — | — | — | — | 18.8 (5.0-39.6) |
ICD-9 indicates International Classification of Diseases, 9th revision; CVD, cardiovascular disease; O, observed number of specific CVDs; E, expected number of specific CVDs; AER, absolute excess risk; —, not available; and NA, not applicable.
Per 10 000 person-years. The absolute incidence rate/10 000 can be calculated with the following formula: AER + AER/(SIR − 1) × 10 000.
Acute myocardial infarction and angina pectoris combined allowing both diagnoses per person; 51 patients had both diagnoses.
Acute myocardial infarction and angina pectoris combined allowing only 1 event per person.
Includes 84 men and 18 women.
Includes 86 men and 48 women.
Congestive heart failure was observed in 59 patients but because reference rates are available from 1986, analyses were based on person-years and events since 1986; 7 patients with CHF before 1986 are excluded from this analysis.
No reference rates available.
In addition to the CVDs mentioned in the table: endocarditis (n = 6), cardiac aneurysm (n = 2) and sudden cardiac death (n = 11). Among patients with more than one CD frequently observed combinations were: CHF with valvular disorders (n = 29), CHF with AP (n = 22), CHF with MI (n = 14), CHF with cardiomyopathy (n = 10), dysrhythmia with MI (n = 14), dysrhythmia with AP (n = 31) and dysrhythmia with valvular disorders (n = 43). Among men in total, 356 cardiac events were observed consisting of MI (23.6%), AP (24.2%), valvular disorders (18.6%), dysrhythmia (12.9%), CHF (7.9%), cardiomyopathy (5.9%), pericarditis (3.4%), endocarditis (<1%), and cardiac aneurysm (<1%). Among women in total, 263 cardiac events were observed consisting of MI (6.8%), AP (18.3%), valvular disorders (35.7%), dysrhythmia (16.3%), CHF (11.8%), cardiomyopathy (4.6%), and pericarditis (4.2%).