Actuarial risk of CHF and cardiomyopathy combined in 5-year survivors of HL according to the Kaplan-Meier method versus cumulative incidence with death from any cause as competing risk
| Treatment group . | Time since diagnosis† . | |||||
|---|---|---|---|---|---|---|
| 10 y, % . | 15 y, % . | 20 y, % . | 25 y, % . | 30 y, % . | 35 y, % . | |
| Actuarial risk according to the Kaplan-Meier method* | ||||||
| No mediastinal RT | 0.4 | 0.4 | 0.4 | 0.4 | 2.5 | 2.5 |
| Mediastinal RT only | 0.0 | 0.6 | 4.5 | 7.5 | 13.9 | 13.9 |
| Mediastinal RT + CT, no anthracyclines | 0.7 | 1.7 | 3.5 | 6.5 | 11.3 | 24.8 |
| Mediastinal RT + anthracyclines | 1.5 | 2.8 | 10.7 | 10.7 | 29.8 | NA |
| All treatments | 0.7 | 1.5 | 4.4 | 6.7 | 12.2 | 20.0 |
| Cumulative incidence with death from any cause as competing risk* | ||||||
| No mediastinal RT | 0.4 | 0.4 | 0.4 | 0.4 | 2.0 | 2.0 |
| Mediastinal RT only | 0.0 | 0.6 | 4.2 | 6.8 | 11.7 | 11.7 |
| Mediastinal RT + CT, no anthracyclines | 0.6 | 1.5 | 2.8 | 4.9 | 7.6 | 14.3 |
| Mediastinal RT + anthracyclines | 1.4 | 2.5 | 7.9 | 7.9 | 15.7 | NA |
| All treatments | 0.6 | 1.3 | 3.7 | 5.4 | 8.9 | 13.1 |
| Treatment group . | Time since diagnosis† . | |||||
|---|---|---|---|---|---|---|
| 10 y, % . | 15 y, % . | 20 y, % . | 25 y, % . | 30 y, % . | 35 y, % . | |
| Actuarial risk according to the Kaplan-Meier method* | ||||||
| No mediastinal RT | 0.4 | 0.4 | 0.4 | 0.4 | 2.5 | 2.5 |
| Mediastinal RT only | 0.0 | 0.6 | 4.5 | 7.5 | 13.9 | 13.9 |
| Mediastinal RT + CT, no anthracyclines | 0.7 | 1.7 | 3.5 | 6.5 | 11.3 | 24.8 |
| Mediastinal RT + anthracyclines | 1.5 | 2.8 | 10.7 | 10.7 | 29.8 | NA |
| All treatments | 0.7 | 1.5 | 4.4 | 6.7 | 12.2 | 20.0 |
| Cumulative incidence with death from any cause as competing risk* | ||||||
| No mediastinal RT | 0.4 | 0.4 | 0.4 | 0.4 | 2.0 | 2.0 |
| Mediastinal RT only | 0.0 | 0.6 | 4.2 | 6.8 | 11.7 | 11.7 |
| Mediastinal RT + CT, no anthracyclines | 0.6 | 1.5 | 2.8 | 4.9 | 7.6 | 14.3 |
| Mediastinal RT + anthracyclines | 1.4 | 2.5 | 7.9 | 7.9 | 15.7 | NA |
| All treatments | 0.6 | 1.3 | 3.7 | 5.4 | 8.9 | 13.1 |
CHF indicates congestive heart failure; RT, radiotherapy; CT, chemotherapy; NA, not applicable because there were no patients at risk in this subgroup.
The median age at diagnosis was similar for the different treatment groups.
Because only patients who survived at least 5 years after HL diagnosis and patients without previous CVDs are included, the cumulative incidence at 5 years is 0% for all patients.