Proposed revised WHO criteria for polycythemia vera
| Proposed criteria for PV . |
|---|
| Major criteria |
| 1. Hemoglobin > 18.5 g/dL in men, 16.5 g/dL in women or other evidence of increased red cell volume* |
| 2. Presence of JAK2617V>F or other functionally similar mutation such as JAK2 exon 12 mutation |
| Minor criteria |
| 1. Bone marrow biopsy showing hypercellularity for age with trilineage growth (panmyelosis) with prominent erythroid, granulocytic, and megakaryocytic proliferation |
| 2. Serum erythropoietin level below the reference range for normal |
| 3. Endogenous erythroid colony formation in vitro |
| Proposed criteria for PV . |
|---|
| Major criteria |
| 1. Hemoglobin > 18.5 g/dL in men, 16.5 g/dL in women or other evidence of increased red cell volume* |
| 2. Presence of JAK2617V>F or other functionally similar mutation such as JAK2 exon 12 mutation |
| Minor criteria |
| 1. Bone marrow biopsy showing hypercellularity for age with trilineage growth (panmyelosis) with prominent erythroid, granulocytic, and megakaryocytic proliferation |
| 2. Serum erythropoietin level below the reference range for normal |
| 3. Endogenous erythroid colony formation in vitro |
Diagnosis requires the presence of both major criteria and 1 minor criterion or the presence of the first major criterion together with 2 minor criteria.
Hemoglobin or hematocrit greater than 99th percentile of method-specific reference range for age, sex, altitude of residence or hemoglobin greater than 17 g/dL in men, 15 g/dL in women if associated with a documented and sustained increase of at least 2 g/dL from an individual's baseline value that can not be attributed to correction of iron deficiency, or elevated red cell mass greater than 25% above mean normal predicted value.