2001 WHO criteria for fibrotic stage primary myelofibrosis
| 2001 criteria for fibrotic PMF . |
|---|
| Clinical findings |
| Spleen and liver |
| Moderate to marked splenomegaly or hepatomegaly |
| Hematology |
| Moderate to marked anemia |
| White blood cells decreased to elevated |
| Platelet count decreased to elevated |
| Morphological findings |
| Blood |
| Leukoerythroblastosis |
| Prominent red blood cell poikilocytosis |
| Prominent dacryocytosis |
| Bone marrow |
| Reticulin and/or collagen fibrosis |
| Decreased cellularity |
| Dilated marrow sinuses |
| Intraluminal hematopoiesis |
| Neutrophilic proliferation |
| Prominent megakaryocytic proliferation |
| Megakaryocytic atypia* |
| New bone formation (osteosclerosis) |
| 2001 criteria for fibrotic PMF . |
|---|
| Clinical findings |
| Spleen and liver |
| Moderate to marked splenomegaly or hepatomegaly |
| Hematology |
| Moderate to marked anemia |
| White blood cells decreased to elevated |
| Platelet count decreased to elevated |
| Morphological findings |
| Blood |
| Leukoerythroblastosis |
| Prominent red blood cell poikilocytosis |
| Prominent dacryocytosis |
| Bone marrow |
| Reticulin and/or collagen fibrosis |
| Decreased cellularity |
| Dilated marrow sinuses |
| Intraluminal hematopoiesis |
| Neutrophilic proliferation |
| Prominent megakaryocytic proliferation |
| Megakaryocytic atypia* |
| New bone formation (osteosclerosis) |
Clustering of megakaryocytes, abnormally lobulated megakaryocytic nuclei, naked megakaryocytic nuclei.