Insertions in known proto-oncogenes, genes with an established role in hematopoiesis, and common insertion sites in the insertional dominance database (IDDb)
| Type of protein and locus . | No. hits in IDDb . | No. hits in RTCGD . | Gene ID . | Chromosome . | Name/(proposed) function . |
|---|---|---|---|---|---|
| Growth factor | |||||
| FasL | 2 | 0 | 14103 | 1 H2.1 | Fas ligand (TNF superfamily, member 6) |
| Vegfa | 1 | 0 | 22339 | 17B3 | Vascular endothelial growth factor A |
| Tnfsf10 | 2 | 2 | 22035 | 3A3 | Tumor necrosis factor (ligand) superfamily, member 10, apoptosis induction |
| Receptor | |||||
| Sema4b | 3 | 4 | 20352 | 7D1 | Receptor activity |
| Axl | 1 | 0 | 26362 | 7A3-B1 | Receptor activity, protein kinase activity, human proto-oncogene |
| Csflr | 1 | 9 | 12978 | 18D | Receptor of colony stimulating factor 1 (CSF-1) |
| Csfr3 | 1 | 0 | 12986 | 4D2+2 | G protein coupled receptor for granulocyte colony stimulating factor (G-CSF) |
| Gpr43 = Ffar2 | 2 | 0 | 233079 | 7A3 | G-protein coupled receptor, free fatty acid receptor |
| Igfbp4 | 2 | 0 | 16010 | 11 D-E1 | Insulin-like growth factor binding protein 4 |
| Ly78 | 2 | 0 | 17079 | 13D1 | Lymphocyte antigen 78, receptor, signaling, CD180 |
| Signal transducer | |||||
| Akt1 | 2 | 3 | 11651 | 12F1-F2 | Intracellular signaling, kinase transforming protein |
| Bcl211 | 1 | 3 | 12048 | 2H1 | Bcl2-like1, antiapoptosis |
| Ccnd3 | 1 | 13 | 12445 | 17B4 | Cyclin D3, cell cycle |
| Mcl1 | 1 | 4 | 17210 | 3F2.1 | Myeloid cell leukemia sequence 1, Bcl2-related antiapoptotic protein |
| Osbpl3 | 1 | 2 | 71720 | 6B3 | Oxysterol binding protein-like 3, steroid metabolism |
| Pim2 | 2 | 5 | 18715 | X A1.1 | Serine/threonine-protein kinase Pim-2, proviral integration site 2, antiapoptosis |
| Plcg2 | 2 | 0 | 234779 | 8E1 | Phospholipase C, gamma 2, survival signaling |
| Rab3gap2 | 2 | 0 | 381313 | 1H5 | Similar to Rab3 GTPase activating protein, gene model 981 |
| Rhof | 1 | 4 | 23912 | 5F | Ras homolog gene family member |
| Sesn2 = Hi95 | 3 | 0 | 230784 | 4D2.3 | Sestrin 2, induction in response to DNA damage |
| Transcription factor | |||||
| 2610510B01Rik = Dopey2 | 1 | 4 | 70028 | 16 C4 | Predicted leucine zipper transcription factor, dopey family |
| Bcll1a | 2 | 6 | 14025 | 11A3+2 | Zinc finger, essential for lymphopoiesis |
| Cbfa2t3h | 1 | 7 | 12398 | 8E1 | Core-binding factor, runt domain, alpha subunit 2, translocated 2, 3 homolog |
| Cutl1 | 1 | 3 | 13047 | 5 G2 | Cut-like 1 (Drosophila) = CCAAT displacement protein = Cux/CDP homeoprotein |
| Elk4 | 1 | 3 | 13714 | 1E3-G | ELK4, ETS family member |
| Evi1 | 13 | 20 | 14013 | 3A3 | Associated with murine and human leukemia, SMAD interacting |
| Fli1 | 2 | 7 | 14247 | 9A4 | ETS family member |
| Fos (LOC627366) | 2 | 5 | 14281 | 12 D2 | FBJ osteosarcoma oncogene |
| Fosb (Erccl) | 1 | 0 | 14282 | 7A2 | FBJ osteosarcoma oncogene B |
| Foxo3a | 2 | 0 | 56484 | 10B2 | Forkhead transcription factor, potentially pro-apoptotic |
| Gtf2i | 2 | 0 | 14886 | 5G2 | General transcription factor 2 |
| Hhex | 1 | 26 | 15242 | 19Cl | Hematopoietically expressed homeobox gene (T-cell oncogene) |
| Hic1 | 3 | 3 | 15248 | 11B5 | Hypermethylated in cancer 1, transcription factor, Wnt antagonism |
| Hivep1 | 1 | 2 | 110521 | 13A4 | HIV enhancer binding protein 1 |
| HoxA7 | 2 | 19 | 15404 | 6B3 | Homeobox gene A7 and surrounding cluster |
| Hoxb4/Hoxb5 | 1 | 0 | 15412 | 11D | Homeobox gene B4 and surrounding cluster |
| Lmo2 | 2 | 2 | 16909 | 2 E2 | LIM domain only 2, T-cell oncogene |
| Mef2d | 1 | 5 | 17261 | 3F1 | Myocyte enhancer factor 2D |
| Mllt3 | 1 | 0 | 70122 | 4C4 | Involved in leukemogenic translocations |
| Runx2 | 1 | 6 | 12393 | 17B3 | Runt related, essential for hematopoiesis |
| Runx3 | 1 | 5 | 12399 | 4D2.3 | Runt related, myeloid development |
| Sox4 | 1 | 64 | 20677 | 13A3-A5 | Sry box, lymphocyte activation |
| Tal1 | 1 | 0 | 21349 | 4D1 | Ebox family member, essential for hematopoiesis |
| Zfp3612 | 1 | 4 | 12193 | 17 E4 | Zinc finger protein 36, C3H type-like |
| Metabolic | |||||
| Dph5 | 2 | 0 | 69740 | 3F3 | DPH5 homolog (Saccharomyces cerevisiae) transferase |
| Unknown | |||||
| Lrrc6 | 2 | 0 | 54562 | 15D1 | Leucin repeat containing 6 (testis) |
| Dym = 4933427L07Rik | 1 | 3 | 69190 | 18 E2 | Dymeclin, function unknown |
| AB041803 | 2 | 8 | 232685 | 6A3.3 | Hypothetical protein, function unknown |
| BC031781 | 1 | 2 | 208768 | 1H4 | Hypothetical protein, function unknown |
| Type of protein and locus . | No. hits in IDDb . | No. hits in RTCGD . | Gene ID . | Chromosome . | Name/(proposed) function . |
|---|---|---|---|---|---|
| Growth factor | |||||
| FasL | 2 | 0 | 14103 | 1 H2.1 | Fas ligand (TNF superfamily, member 6) |
| Vegfa | 1 | 0 | 22339 | 17B3 | Vascular endothelial growth factor A |
| Tnfsf10 | 2 | 2 | 22035 | 3A3 | Tumor necrosis factor (ligand) superfamily, member 10, apoptosis induction |
| Receptor | |||||
| Sema4b | 3 | 4 | 20352 | 7D1 | Receptor activity |
| Axl | 1 | 0 | 26362 | 7A3-B1 | Receptor activity, protein kinase activity, human proto-oncogene |
| Csflr | 1 | 9 | 12978 | 18D | Receptor of colony stimulating factor 1 (CSF-1) |
| Csfr3 | 1 | 0 | 12986 | 4D2+2 | G protein coupled receptor for granulocyte colony stimulating factor (G-CSF) |
| Gpr43 = Ffar2 | 2 | 0 | 233079 | 7A3 | G-protein coupled receptor, free fatty acid receptor |
| Igfbp4 | 2 | 0 | 16010 | 11 D-E1 | Insulin-like growth factor binding protein 4 |
| Ly78 | 2 | 0 | 17079 | 13D1 | Lymphocyte antigen 78, receptor, signaling, CD180 |
| Signal transducer | |||||
| Akt1 | 2 | 3 | 11651 | 12F1-F2 | Intracellular signaling, kinase transforming protein |
| Bcl211 | 1 | 3 | 12048 | 2H1 | Bcl2-like1, antiapoptosis |
| Ccnd3 | 1 | 13 | 12445 | 17B4 | Cyclin D3, cell cycle |
| Mcl1 | 1 | 4 | 17210 | 3F2.1 | Myeloid cell leukemia sequence 1, Bcl2-related antiapoptotic protein |
| Osbpl3 | 1 | 2 | 71720 | 6B3 | Oxysterol binding protein-like 3, steroid metabolism |
| Pim2 | 2 | 5 | 18715 | X A1.1 | Serine/threonine-protein kinase Pim-2, proviral integration site 2, antiapoptosis |
| Plcg2 | 2 | 0 | 234779 | 8E1 | Phospholipase C, gamma 2, survival signaling |
| Rab3gap2 | 2 | 0 | 381313 | 1H5 | Similar to Rab3 GTPase activating protein, gene model 981 |
| Rhof | 1 | 4 | 23912 | 5F | Ras homolog gene family member |
| Sesn2 = Hi95 | 3 | 0 | 230784 | 4D2.3 | Sestrin 2, induction in response to DNA damage |
| Transcription factor | |||||
| 2610510B01Rik = Dopey2 | 1 | 4 | 70028 | 16 C4 | Predicted leucine zipper transcription factor, dopey family |
| Bcll1a | 2 | 6 | 14025 | 11A3+2 | Zinc finger, essential for lymphopoiesis |
| Cbfa2t3h | 1 | 7 | 12398 | 8E1 | Core-binding factor, runt domain, alpha subunit 2, translocated 2, 3 homolog |
| Cutl1 | 1 | 3 | 13047 | 5 G2 | Cut-like 1 (Drosophila) = CCAAT displacement protein = Cux/CDP homeoprotein |
| Elk4 | 1 | 3 | 13714 | 1E3-G | ELK4, ETS family member |
| Evi1 | 13 | 20 | 14013 | 3A3 | Associated with murine and human leukemia, SMAD interacting |
| Fli1 | 2 | 7 | 14247 | 9A4 | ETS family member |
| Fos (LOC627366) | 2 | 5 | 14281 | 12 D2 | FBJ osteosarcoma oncogene |
| Fosb (Erccl) | 1 | 0 | 14282 | 7A2 | FBJ osteosarcoma oncogene B |
| Foxo3a | 2 | 0 | 56484 | 10B2 | Forkhead transcription factor, potentially pro-apoptotic |
| Gtf2i | 2 | 0 | 14886 | 5G2 | General transcription factor 2 |
| Hhex | 1 | 26 | 15242 | 19Cl | Hematopoietically expressed homeobox gene (T-cell oncogene) |
| Hic1 | 3 | 3 | 15248 | 11B5 | Hypermethylated in cancer 1, transcription factor, Wnt antagonism |
| Hivep1 | 1 | 2 | 110521 | 13A4 | HIV enhancer binding protein 1 |
| HoxA7 | 2 | 19 | 15404 | 6B3 | Homeobox gene A7 and surrounding cluster |
| Hoxb4/Hoxb5 | 1 | 0 | 15412 | 11D | Homeobox gene B4 and surrounding cluster |
| Lmo2 | 2 | 2 | 16909 | 2 E2 | LIM domain only 2, T-cell oncogene |
| Mef2d | 1 | 5 | 17261 | 3F1 | Myocyte enhancer factor 2D |
| Mllt3 | 1 | 0 | 70122 | 4C4 | Involved in leukemogenic translocations |
| Runx2 | 1 | 6 | 12393 | 17B3 | Runt related, essential for hematopoiesis |
| Runx3 | 1 | 5 | 12399 | 4D2.3 | Runt related, myeloid development |
| Sox4 | 1 | 64 | 20677 | 13A3-A5 | Sry box, lymphocyte activation |
| Tal1 | 1 | 0 | 21349 | 4D1 | Ebox family member, essential for hematopoiesis |
| Zfp3612 | 1 | 4 | 12193 | 17 E4 | Zinc finger protein 36, C3H type-like |
| Metabolic | |||||
| Dph5 | 2 | 0 | 69740 | 3F3 | DPH5 homolog (Saccharomyces cerevisiae) transferase |
| Unknown | |||||
| Lrrc6 | 2 | 0 | 54562 | 15D1 | Leucin repeat containing 6 (testis) |
| Dym = 4933427L07Rik | 1 | 3 | 69190 | 18 E2 | Dymeclin, function unknown |
| AB041803 | 2 | 8 | 232685 | 6A3.3 | Hypothetical protein, function unknown |
| BC031781 | 1 | 2 | 208768 | 1H4 | Hypothetical protein, function unknown |
The classification of proto-oncogenes follows the listing in the retrovirus-tagged cancer gene database (RTCGD; http://rtcgd.ncifcrf.gov/) and additional literature. A version of the table with the gene ID configured as a hyperlink to NCBI Entrez Gene (http://www.ncbi.nlm.nih.gov/entrez/) is available from the authors (http://www99.mh-hannover.de/kliniken/zellth/method.html). In the case of Fos and Fosb, Table S1 lists the loci shown in brackets.
Equals sign indicates alternative gene names.