Ingenuity pathway analysis of all genes listed in the IDDb (24 most significant results shown)
| Pathway . | Significance . | Genes . |
|---|---|---|
| p38 MAPK signaling | < .001 | Max, Faslg, Map3k5, Mef2d, Illr1, H3f3a, Ddit3 |
| Death receptor signaling | .001 | Faslg, Map3k5, Map3k14, Tnfsf10, Cflar |
| PDGF signaling | .002 | Pdgfrb, Crk, Fos, Sos1, Plcg2 |
| Endoplasmic reticulum stress pathway | .002 | Ern1, Map3k5, Atf6 |
| PPAR signaling | .004 | Pdgfrb, Fos, Map3k14, Il1r1, Sos1 |
| IGF-1 signaling | .004 | Fos, Sos1, Foxo3a, Igfbp4, Akt1 |
| B-cell receptor signaling | .010 | Map3k5, Map3k14, Gab2, Sos1, Plcg2, Akt1 |
| PI3K/AKT signaling | .013 | Map3k5, RHEB, Gab2, Sos1, Akt1 |
| VEGF signaling | .020 | VEGF, Sos1, Plcg2, Akt1 |
| Neuregulin signaling | .021 | Crk, Sos1, Plcg2, Akt1 |
| PTEN signaling | .023 | Faslg, Sos1, Foxo3a, Akt1 |
| IL-6 signaling | .023 | Fos, Map3k14, Il1r1, Sos1 |
| Insulin receptor signaling | .023 | Crk, Sos1, Stxbp4, Foxo3a, Akt1 |
| Apoptosis signaling | .023 | Faslg, Map3k5, Map3k14, Plcg2 |
| IL-2 signaling | .026 | Fos, Sos1, Akt1 |
| Hypoxia signaling in the cardiovascular system | .032 | Vegf, Hic1, Akt1 |
| Neurotrophin/Trk signaling | .041 | Fos, Sos1, Akt1 |
| Natural killer cell signaling | .043 | Sos1, Klrb1c, Plcg2, Akt1 |
| ERK/MAPK signaling | .045 | Crk, Fos, Sos1, H3f3a, Plcg2 |
| FGF signaling | .048 | Crk, Map3k5, Sos1 |
| IL-10 signaling | .068 | Fos, Map3k14, Il1r1 |
| NF-κB signaling | .091 | Map3k14, Il1r1, Plcg2, Akt1 |
| SAPK/JNK signaling | .104 | Crk, Map3k5, Sos1 |
| Ephrin receptor signaling | .106 | Vegf, Crk, Sos1, Akt1 |
| Pathway . | Significance . | Genes . |
|---|---|---|
| p38 MAPK signaling | < .001 | Max, Faslg, Map3k5, Mef2d, Illr1, H3f3a, Ddit3 |
| Death receptor signaling | .001 | Faslg, Map3k5, Map3k14, Tnfsf10, Cflar |
| PDGF signaling | .002 | Pdgfrb, Crk, Fos, Sos1, Plcg2 |
| Endoplasmic reticulum stress pathway | .002 | Ern1, Map3k5, Atf6 |
| PPAR signaling | .004 | Pdgfrb, Fos, Map3k14, Il1r1, Sos1 |
| IGF-1 signaling | .004 | Fos, Sos1, Foxo3a, Igfbp4, Akt1 |
| B-cell receptor signaling | .010 | Map3k5, Map3k14, Gab2, Sos1, Plcg2, Akt1 |
| PI3K/AKT signaling | .013 | Map3k5, RHEB, Gab2, Sos1, Akt1 |
| VEGF signaling | .020 | VEGF, Sos1, Plcg2, Akt1 |
| Neuregulin signaling | .021 | Crk, Sos1, Plcg2, Akt1 |
| PTEN signaling | .023 | Faslg, Sos1, Foxo3a, Akt1 |
| IL-6 signaling | .023 | Fos, Map3k14, Il1r1, Sos1 |
| Insulin receptor signaling | .023 | Crk, Sos1, Stxbp4, Foxo3a, Akt1 |
| Apoptosis signaling | .023 | Faslg, Map3k5, Map3k14, Plcg2 |
| IL-2 signaling | .026 | Fos, Sos1, Akt1 |
| Hypoxia signaling in the cardiovascular system | .032 | Vegf, Hic1, Akt1 |
| Neurotrophin/Trk signaling | .041 | Fos, Sos1, Akt1 |
| Natural killer cell signaling | .043 | Sos1, Klrb1c, Plcg2, Akt1 |
| ERK/MAPK signaling | .045 | Crk, Fos, Sos1, H3f3a, Plcg2 |
| FGF signaling | .048 | Crk, Map3k5, Sos1 |
| IL-10 signaling | .068 | Fos, Map3k14, Il1r1 |
| NF-κB signaling | .091 | Map3k14, Il1r1, Plcg2, Akt1 |
| SAPK/JNK signaling | .104 | Crk, Map3k5, Sos1 |
| Ephrin receptor signaling | .106 | Vegf, Crk, Sos1, Akt1 |
For comparison, only 2 metabolic pathways were represented with more than one gene in the IDDb (purine metabolism, inositol phosphate metabolism).