Table 3

Univariate analysis of prognostic factors in patients with nasal NK/T-cell lymphoma

Prognostic factorNo. of patientsEstimated OS 5-y rate, %PEstimated EFS 5-y rate, %P
Expression of P19*   .009  .02 
    Positive, more than 10% of tumor cells 26 64 ± 9†  61 ± 10†  
    Negative 10% or less of tumor cells 13 23 ± 11†  23 ± 12†  
Apoptotic index*   .05  .08 
    Low, 10 or fewer cells/hpf 25 36 ± 10†  32 ± 10†  
    High, more than 10 cells/hpf 12 67 ± 14†  58 ± 14†  
IPI score   .06  .2 
    Lower than 2 31 59 ± 9†  47  
    Higher than 2 17 29 ± 11†  29  
Histology   .4  .3 
    Small/medium cells 22 43  39  
    Medium/large cells 26 53  49  
Expression of aC3*   .8  .7 
    Low, fewer than 10 tumor cells 23 43  39  
    High, 10 or more tumor cells 13 46  38  
Prognostic factorNo. of patientsEstimated OS 5-y rate, %PEstimated EFS 5-y rate, %P
Expression of P19*   .009  .02 
    Positive, more than 10% of tumor cells 26 64 ± 9†  61 ± 10†  
    Negative 10% or less of tumor cells 13 23 ± 11†  23 ± 12†  
Apoptotic index*   .05  .08 
    Low, 10 or fewer cells/hpf 25 36 ± 10†  32 ± 10†  
    High, more than 10 cells/hpf 12 67 ± 14†  58 ± 14†  
IPI score   .06  .2 
    Lower than 2 31 59 ± 9†  47  
    Higher than 2 17 29 ± 11†  29  
Histology   .4  .3 
    Small/medium cells 22 43  39  
    Medium/large cells 26 53  49  
Expression of aC3*   .8  .7 
    Low, fewer than 10 tumor cells 23 43  39  
    High, 10 or more tumor cells 13 46  38  
*

In 11 cases, the small size of the sections or abundant areas of necrosis did not allow the assessment of the number of apoptotic cells on 20 hpf's. Due to insufficient tissue or inadequate staining, a few cases could not be evaluated for expression of PI9 (n = 9) and aC3 (n = 13).

†

95% CI.

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