Nonhematologic and hematologic toxicities of clofarabine followed by cyclophosphamide
| Toxicity . | Dose level 1 . | Dose level 0 . |
|---|---|---|
| No. patients | 6 | 12 |
| Clofarabine-related fever | 2 | 4 |
| Tumor lysis syndrome | 3; 1 grade 3 | 4; all grade ≤ 2 |
| Cytokine release/ARDS | 1 grade 3 | 1 grade 5 |
| Renal failure | 0 | 3; 2 grade 4 |
| Hepatic dysfunction | 4; all grade 3 | 2; 1 grade 3 |
| Multiorgan dysfunction | 1 grade 5 | 2; 1 grade 5 |
| Marrow aplasia longer than 42 d | 4*; 1 grade 5 | 3† |
| Documented infections | 8 events/5 patients | 7 events/6 patients |
| Bacteremia, Gram positive | 2; 1 grade 5 | 2 |
| Meningitis, S epidermis | 1 | |
| Ischemic colitis | 1 grade 5 | 0 |
| Fungal pneumonia | 4 | 3; 1 grade 5 |
| Death, no. patients (%) | 2 (33) | 2 (17) |
| Prolonged marrow aplasia | 1 | 0 |
| Fungal pneumonia | 0 | 1 |
| Multiorgan failure | 1 with ischemic colitis | 1 |
| Toxicity . | Dose level 1 . | Dose level 0 . |
|---|---|---|
| No. patients | 6 | 12 |
| Clofarabine-related fever | 2 | 4 |
| Tumor lysis syndrome | 3; 1 grade 3 | 4; all grade ≤ 2 |
| Cytokine release/ARDS | 1 grade 3 | 1 grade 5 |
| Renal failure | 0 | 3; 2 grade 4 |
| Hepatic dysfunction | 4; all grade 3 | 2; 1 grade 3 |
| Multiorgan dysfunction | 1 grade 5 | 2; 1 grade 5 |
| Marrow aplasia longer than 42 d | 4*; 1 grade 5 | 3† |
| Documented infections | 8 events/5 patients | 7 events/6 patients |
| Bacteremia, Gram positive | 2; 1 grade 5 | 2 |
| Meningitis, S epidermis | 1 | |
| Ischemic colitis | 1 grade 5 | 0 |
| Fungal pneumonia | 4 | 3; 1 grade 5 |
| Death, no. patients (%) | 2 (33) | 2 (17) |
| Prolonged marrow aplasia | 1 | 0 |
| Fungal pneumonia | 0 | 1 |
| Multiorgan failure | 1 with ischemic colitis | 1 |