Effects of 100NA,RO-H on in vivo growth of CAG heparanase-high myeloma cells
| Mouse tag no. . | 100NA,RO-H, mg/kg per d . | Tumor wet weight,* mg . | Serum kappa light chain,† ng/mL . |
|---|---|---|---|
| OBOB | 0 | 1390 | 23 271 |
| OA14 | 0 | 350 | 4 796 |
| 1310 | 0 | 240 | 2 419 |
| 176D | 0 | 170 | 2 265 |
| 2A0C | 0 | 100 | 3 956 |
| 532B | 18 | 80 | 582 |
| 3D4A | 18 | 50 | 482 |
| 7003 | 18 | 30 | 34 |
| 956 | 18 | 20 | 101 |
| 283C | 18 | 10 | 26 |
| 6464 | 18 | 1 | 5 |
| 4972 | 18 | 0 | 0 |
| 6D6B | 36 | 5 | 197 |
| 5A67 | 36 | 0 | 0 |
| 737 | 36 | 0 | 2 |
| 7253 | 36 | 0 | 0 |
| 7670 | 36 | 0 | 5 |
| 7732 | 36 | 0 | 0 |
| Mouse tag no. . | 100NA,RO-H, mg/kg per d . | Tumor wet weight,* mg . | Serum kappa light chain,† ng/mL . |
|---|---|---|---|
| OBOB | 0 | 1390 | 23 271 |
| OA14 | 0 | 350 | 4 796 |
| 1310 | 0 | 240 | 2 419 |
| 176D | 0 | 170 | 2 265 |
| 2A0C | 0 | 100 | 3 956 |
| 532B | 18 | 80 | 582 |
| 3D4A | 18 | 50 | 482 |
| 7003 | 18 | 30 | 34 |
| 956 | 18 | 20 | 101 |
| 283C | 18 | 10 | 26 |
| 6464 | 18 | 1 | 5 |
| 4972 | 18 | 0 | 0 |
| 6D6B | 36 | 5 | 197 |
| 5A67 | 36 | 0 | 0 |
| 737 | 36 | 0 | 2 |
| 7253 | 36 | 0 | 0 |
| 7670 | 36 | 0 | 5 |
| 7732 | 36 | 0 | 0 |
Mean tumor weights: No 100NA,RO-H, 450 mg; 18 mg/kg per day group, 30 mg; 36 mg/kg per day group (1 tumor only), 5 mg. No 100NA,RO-H group versus 18 mg/kg per day group, P = .029. No 100NA,RO-H group versus 36 mg/kg per day group, P = .033.
Mean kappa levels at termination of treatment: No 100NA,RO-H = 7341 ng; 18 mg/kg per day group, 176 ng; 36 mg/kg per day group (1 tumor only), 34 ng. No 100NA,RO-H group versus 18 mg/kg per day group, P = .028. No 100NA,RO-H group versus 36 mg/kg per day group, P = .037.