Age-stratified Cox proportional hazards analysis of overall survival in poor prognostic subgroups
| Variable . | Younger than 70 y . | 70 y or older . | All ages . | |||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| CLLU1 at least 40-fold | 3.63 (1.96-6.73) | <.001 | 1.14 (0.69-1.88) | .61 | 1.81 (1.25-2.64) | .002 |
| Binet stage B or C | 2.53 (1.40-4.57) | .002 | 1.52 (0.93-2.48) | .094 | 2.09 (2.08-3.04) | <.001 |
| Unmutated IgVH | 6.04 (2.99-12.20) | <.001 | 2.20 (1.22-3.97) | .007 | 3.53 (2.26-5.51) | <.001 |
| ZAP-70 at least 20% | 4.02 (1.76-9.20) | <.001 | 1.36 (0.72-2.58) | .35 | 2.31 (1.40-3.81) | .001 |
| CD38 at least 20% | 1.91 (0.93-3.90) | .072 | 2.35 (1.27-4.34) | .005 | 2.20 (1.38-3.49) | .001 |
| del(17p)/del(11q) | 3.01 (1.34-6.74) | .005 | 3.43 (1.78-6.62) | <.001 | 3.55 (2.14-5.87) | <.001 |
| Variable . | Younger than 70 y . | 70 y or older . | All ages . | |||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| CLLU1 at least 40-fold | 3.63 (1.96-6.73) | <.001 | 1.14 (0.69-1.88) | .61 | 1.81 (1.25-2.64) | .002 |
| Binet stage B or C | 2.53 (1.40-4.57) | .002 | 1.52 (0.93-2.48) | .094 | 2.09 (2.08-3.04) | <.001 |
| Unmutated IgVH | 6.04 (2.99-12.20) | <.001 | 2.20 (1.22-3.97) | .007 | 3.53 (2.26-5.51) | <.001 |
| ZAP-70 at least 20% | 4.02 (1.76-9.20) | <.001 | 1.36 (0.72-2.58) | .35 | 2.31 (1.40-3.81) | .001 |
| CD38 at least 20% | 1.91 (0.93-3.90) | .072 | 2.35 (1.27-4.34) | .005 | 2.20 (1.38-3.49) | .001 |
| del(17p)/del(11q) | 3.01 (1.34-6.74) | .005 | 3.43 (1.78-6.62) | <.001 | 3.55 (2.14-5.87) | <.001 |