Table 3

Clinical data for patients with HPSEhigh and HPSElow

HPSElow, %HPSEhigh, %P
Age at least 65 y 13 27 .36 
β2-microglobulin level 
    Less than 3.5 mg/L 80* 47* .05* 
    Greater than 5.5 mg/L 0* 27* .03* 
C-reactive protein level greater than 5 mg/L 7* 40* .03* 
Lactate dehydrogenase level at least 240 IU/L 20 27 .66 
Albumin level less than 35 g/L 33 40 .7 
Hemoglobin level less than 10 g/dL 20 47 .1 
Ca++ level less than 2.65 mM 100 100 > .999 
κ Light chain 67 53 .45 
λ Light chain 33 47 .45 
IgA subtype 20 13 .61 
Bone lesions, major structural damage (≥3) 15 23 .61 
t(4;14) 15 0 .14 
del(chr13) 62 46 .39 
DS classification   .82 
    Stage I 13 7  
    Stage II 20 20  
    Stage III 67 73  
ISS classification   .008* 
    Stage I 47* 7*  
    Stage II 53* 60*  
    Stage III 0* 33*  
HPSElow, %HPSEhigh, %P
Age at least 65 y 13 27 .36 
β2-microglobulin level 
    Less than 3.5 mg/L 80* 47* .05* 
    Greater than 5.5 mg/L 0* 27* .03* 
C-reactive protein level greater than 5 mg/L 7* 40* .03* 
Lactate dehydrogenase level at least 240 IU/L 20 27 .66 
Albumin level less than 35 g/L 33 40 .7 
Hemoglobin level less than 10 g/dL 20 47 .1 
Ca++ level less than 2.65 mM 100 100 > .999 
κ Light chain 67 53 .45 
λ Light chain 33 47 .45 
IgA subtype 20 13 .61 
Bone lesions, major structural damage (≥3) 15 23 .61 
t(4;14) 15 0 .14 
del(chr13) 62 46 .39 
DS classification   .82 
    Stage I 13 7  
    Stage II 20 20  
    Stage III 67 73  
ISS classification   .008* 
    Stage I 47* 7*  
    Stage II 53* 60*  
    Stage III 0* 33*  

Thirty patients with newly diagnosed MM were separated in 2 subgroups of 15 patients each (HPSEhigh and HPSElow), according to HPSE gene expression in the WBM and assayed with Affymetrix U133 microarrays. Data are the percentages of patients within each subgroup with the indicated clinical or biologic parameters. Statistical comparisons were made with the chi-square test.

To convert β2-microglobulin level from milligrams per liter to nanomoles per liter, multiply milligrams per liter by 85. To convert hemoglobin level from grams per deciliter to grams per liter, multiply grams per deciliter by 10.

*

The percentages between the 2 groups are significantly different.

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