Table 3 Algorithm for the diagnosis of... | American Society of Hematology

Table 3

Algorithm for the diagnosis of early MF¹⁵

Criteria	Major (2 points)	Minor (1 point)
Clinical
Persistent and/or progressive patches and plaques plus	Any 2	Any 1
(1) Non–sun-exposed location
(2) Size/shape variation
(3) Poikiloderma
Histopathologic
Superficial lymphoid infiltrate plus	Both	Either
(1) Epidermotropism without spongiosis
(2) Lymphoid atypia*
Molecular/biologic: clonal TCR gene rearrangement	NA†	Present
Immunopathologic
(1) CD2,3,5 less than 50% of T cells	NA†	Any 1
(2) CD7 less than 10% of T cells
(3) Epidermal discordance from expression of CD2,3,5 or CD7 on dermal T cells

Criteria	Major (2 points)	Minor (1 point)
Clinical
Persistent and/or progressive patches and plaques plus	Any 2	Any 1
(1) Non–sun-exposed location
(2) Size/shape variation
(3) Poikiloderma
Histopathologic
Superficial lymphoid infiltrate plus	Both	Either
(1) Epidermotropism without spongiosis
(2) Lymphoid atypia*
Molecular/biologic: clonal TCR gene rearrangement	NA†	Present
Immunopathologic
(1) CD2,3,5 less than 50% of T cells	NA†	Any 1
(2) CD7 less than 10% of T cells
(3) Epidermal discordance from expression of CD2,3,5 or CD7 on dermal T cells

— indicates not applicable.

Lymphoid atypia is defined as cells with enlarged hyperchromatic nuclei and irregular or cerebriform nuclear contours.

Not applicable since it cannot fulfill any major criteria.