Pathways discriminating among hierarchical cluster-defined CBF subgroups
| Pathway description . | Pathway ID . | No. of genes . | LS permutation . | KS permutation . |
|---|---|---|---|---|
| MAPK signaling pathway | BioCarta: h_mapkPathway | 69 | <.001 | <.001 |
| Stathmin and breast cancer resistance to antimicrotubule agents | BioCarta: h_stathminPathway | 10 | <.001 | .002 |
| Role of mitochondria in apoptotic signaling | BioCarta: h_mitochondriaPathway | 14 | <.001 | .025 |
| p38 MAPK signaling pathway | BioCarta: h_p38mapkPathway | 29 | <.001 | .022 |
| Caspase cascade in apoptosis | BioCarta: h_caspasePathway | 15 | <.001 | .002 |
| Pyrimidine metabolism | Kegg: hsa00240 | 38 | .001 | .003 |
| SODD/TNFR1 signaling pathway | BioCarta: h_soddPathway | 9 | .002 | .021 |
| Bone remodeling | BioCarta: h_rank1Pathway | 17 | .002 | .004 |
| PRC2 complex (long-term gene silencing through modification of histone tails) | BioCarta: h_prc2Pathway | 6 | .003 | .062 |
| FAS signaling pathway (CD95) | BioCarta: h_fasPathway | 24 | .016 | .002 |
| TNFR1 signaling pathway | BioCarta: h_tnfr1Pathway | 27 | .018 | .002 |
| IFN gamma signaling pathway | BioCarta: h_ifngPathway | 6 | .020 | .001 |
| Role of PI3K subunit p85 in regulation of actin organization and cell migration | BioCarta: h_cdc42racPathway | 6 | .025 | .004 |
| Signaling of hepatocyte growth factor receptor | BioCarta: h_metPathway | 35 | .026 | .004 |
| Ceramide signaling pathway | BioCarta: h_ceramidePathway | 20 | .072 | <.001 |
| Pathway description . | Pathway ID . | No. of genes . | LS permutation . | KS permutation . |
|---|---|---|---|---|
| MAPK signaling pathway | BioCarta: h_mapkPathway | 69 | <.001 | <.001 |
| Stathmin and breast cancer resistance to antimicrotubule agents | BioCarta: h_stathminPathway | 10 | <.001 | .002 |
| Role of mitochondria in apoptotic signaling | BioCarta: h_mitochondriaPathway | 14 | <.001 | .025 |
| p38 MAPK signaling pathway | BioCarta: h_p38mapkPathway | 29 | <.001 | .022 |
| Caspase cascade in apoptosis | BioCarta: h_caspasePathway | 15 | <.001 | .002 |
| Pyrimidine metabolism | Kegg: hsa00240 | 38 | .001 | .003 |
| SODD/TNFR1 signaling pathway | BioCarta: h_soddPathway | 9 | .002 | .021 |
| Bone remodeling | BioCarta: h_rank1Pathway | 17 | .002 | .004 |
| PRC2 complex (long-term gene silencing through modification of histone tails) | BioCarta: h_prc2Pathway | 6 | .003 | .062 |
| FAS signaling pathway (CD95) | BioCarta: h_fasPathway | 24 | .016 | .002 |
| TNFR1 signaling pathway | BioCarta: h_tnfr1Pathway | 27 | .018 | .002 |
| IFN gamma signaling pathway | BioCarta: h_ifngPathway | 6 | .020 | .001 |
| Role of PI3K subunit p85 in regulation of actin organization and cell migration | BioCarta: h_cdc42racPathway | 6 | .025 | .004 |
| Signaling of hepatocyte growth factor receptor | BioCarta: h_metPathway | 35 | .026 | .004 |
| Ceramide signaling pathway | BioCarta: h_ceramidePathway | 20 | .072 | <.001 |
Number of genes used for random variance estimation: 8556; number of investigated pathways: 233 BioCarta and 76 KEGG pathways (309 total); table sorted by P value of the LS permutation test; the first 15 pathways are significant at the nominal .005 level of the LS permutation test or KS permutation test.