Table 4 Association of single SNPs using... | American Society of Hematology

Table 4

Association of single SNPs using the WHAP method

Gene	SNP ID	P by WHAP			Adjusted P by WHAP
Gene	SNP ID	Additive model	Dominant model	Recessive model	Additive model	Dominant model	Recessive model
BCL2	rs1801018	.09*	.15	.20	.06*	.12	.10
BCL2	rs2279115	.03†	.12	.05*	.07*	.28	.07*
BAX	rs11667351	.14	.24	.16	.05*	.06*	.24
BCL6	rs1056932	.38	.63	.28	.56	.65	.07*
CASP3	rs1049253	.16	.09*	.92	.09*	.16	.11
CASP7	rs7922608	.05†	.12	.09*	.04*	.14	.05*
CASP8	rs1045485	.57	.27	.26	.56	.30	.44
CASP8	rs3769818	.70	.29	.26	.37	.89	.04†
CASP8	RS3834129	.36	.66	.28	.12	.18	.24
CASP10	rs13010627	.35	.32	.96	.05*	.04†	.79
CASP10	rs13006529	.29	.58	.22	.09*	.16	.18
FAS	rs2234767	.91	.68	.37	.87	.76	.20
FAS	rs1800682	.22	.09*	.80	.64	.17	.50
VEGFA	rs699947	.01†	.05†	.04†	.10*	.47	.04†
VEGFA	rs833061	.02†	.07*	.06*	.16	.60	.07*
VEGFA	rs2010963	.08*	.12	.21	.30	.48	.28
VEGFR2	rs1531289	.22	.13	.86	<.001†	.55	<.001†
VEGFR2	rs1870377	.96	.74	.40	.92	.90	.62
VEGFR2	rs2305948	.17	.25	.10	.43	.47	.52
CSF3	rs25645	.60	.38	.80	.30	.26	.66
CSF3	rs1042658	.06*	.09*	.21	.65	.82	.54
JAK3	rs3008	.09*	.15	.18	.77	.80	.41
JAK3	rs3212713	.15	.54	.04†	.52	.44	.93
IL1R	rs2228139	.45	.63	.10	.26	.42	.09*
WT1	rs1799937	.16	.24	.26	.09*	.18	.13
CYP3A5	rs776746	.11	.13	.34	.03†	.03†	.32
HOCT1	rs1867351	.76	.83	.21	.78	.82	.81
HOCT1	rs12208357	.26	.31	.25	.36	.37	.77
HOCT1	rs683369	.85	.94	.40	.76	.89	.56
HOCT1	rs2282143	.05*	.05*	>.99	.54	.54	>.99
HOCT1	rs628031	.72	.64	.96	.47	.89	.13

Gene	SNP ID	P by WHAP			Adjusted P by WHAP
Gene	SNP ID	Additive model	Dominant model	Recessive model	Additive model	Dominant model	Recessive model
BCL2	rs1801018	.09*	.15	.20	.06*	.12	.10
BCL2	rs2279115	.03†	.12	.05*	.07*	.28	.07*
BAX	rs11667351	.14	.24	.16	.05*	.06*	.24
BCL6	rs1056932	.38	.63	.28	.56	.65	.07*
CASP3	rs1049253	.16	.09*	.92	.09*	.16	.11
CASP7	rs7922608	.05†	.12	.09*	.04*	.14	.05*
CASP8	rs1045485	.57	.27	.26	.56	.30	.44
CASP8	rs3769818	.70	.29	.26	.37	.89	.04†
CASP8	RS3834129	.36	.66	.28	.12	.18	.24
CASP10	rs13010627	.35	.32	.96	.05*	.04†	.79
CASP10	rs13006529	.29	.58	.22	.09*	.16	.18
FAS	rs2234767	.91	.68	.37	.87	.76	.20
FAS	rs1800682	.22	.09*	.80	.64	.17	.50
VEGFA	rs699947	.01†	.05†	.04†	.10*	.47	.04†
VEGFA	rs833061	.02†	.07*	.06*	.16	.60	.07*
VEGFA	rs2010963	.08*	.12	.21	.30	.48	.28
VEGFR2	rs1531289	.22	.13	.86	<.001†	.55	<.001†
VEGFR2	rs1870377	.96	.74	.40	.92	.90	.62
VEGFR2	rs2305948	.17	.25	.10	.43	.47	.52
CSF3	rs25645	.60	.38	.80	.30	.26	.66
CSF3	rs1042658	.06*	.09*	.21	.65	.82	.54
JAK3	rs3008	.09*	.15	.18	.77	.80	.41
JAK3	rs3212713	.15	.54	.04†	.52	.44	.93
IL1R	rs2228139	.45	.63	.10	.26	.42	.09*
WT1	rs1799937	.16	.24	.26	.09*	.18	.13
CYP3A5	rs776746	.11	.13	.34	.03†	.03†	.32
HOCT1	rs1867351	.76	.83	.21	.78	.82	.81
HOCT1	rs12208357	.26	.31	.25	.36	.37	.77
HOCT1	rs683369	.85	.94	.40	.76	.89	.56
HOCT1	rs2282143	.05*	.05*	>.99	.54	.54	>.99
HOCT1	rs628031	.72	.64	.96	.47	.89	.13

P < .1.

P < .05.