Clinical outcome in FLT3/TKD− and FLT3/TKD+ non-APL AML patients
| . | TKD−, % . | TKD+, % . | OR (CI); P . | Adjusted result: OR (CI); P . | TKD low, % . | TKD high, % . | OR (CI); P . | Adjusted result: OR (CI); P . |
|---|---|---|---|---|---|---|---|---|
| Initial response to therapy | ||||||||
| CR | 84 | 88 | 0.73 (0.44-1.21); .2 | 0.80 (0.38-1.69); .6 | 83 | 94 | 0.72 (0.49-1.06); .07 | 0.74 (0.44-1.29); .3 |
| ID | 6 | 4 | 0.68 (0.31-1.50); .3 | 0.64 (0.19-2.15); .5 | 6 | 2 | 0.65 (0.33-1.28); .17 | 0.57 (0.22-1.47); .2 |
| RD | 10 | 8 | 0.79 (0.42-1.48); .5 | 0.94 (0.38-2.28); .9 | 11 | 5 | 0.78 (0.49-1.24); .3 | 0.87 (0.48-1.57); .6 |
| Outcome at 5 y | ||||||||
| CIR | 48 | 39 | 0.75 (0.57-0.98); .03 | 0.75 (0.53-1.07); .11 | 50 | 30 | 0.78 (0.64-0.94); .01 | 0.80 (0.64-1.00); .05 |
| RFS | 35 | 48 | 0.74 (0.59-0.93); .008 | 0.71 (0.52-0.97); .03 | 35 | 60 | 0.77 (0.65-0.91); .003 | 0.78 (0.64-0.95); .01 |
| OS | 37 | 53 | 0.72 (0.58-0.89); .002 | 0.71 (0.52-0.96); .03 | 37 | 71 | 0.74 (0.63-0.87); .004 | 0.74 (0.61-0.91); .004 |
| . | TKD−, % . | TKD+, % . | OR (CI); P . | Adjusted result: OR (CI); P . | TKD low, % . | TKD high, % . | OR (CI); P . | Adjusted result: OR (CI); P . |
|---|---|---|---|---|---|---|---|---|
| Initial response to therapy | ||||||||
| CR | 84 | 88 | 0.73 (0.44-1.21); .2 | 0.80 (0.38-1.69); .6 | 83 | 94 | 0.72 (0.49-1.06); .07 | 0.74 (0.44-1.29); .3 |
| ID | 6 | 4 | 0.68 (0.31-1.50); .3 | 0.64 (0.19-2.15); .5 | 6 | 2 | 0.65 (0.33-1.28); .17 | 0.57 (0.22-1.47); .2 |
| RD | 10 | 8 | 0.79 (0.42-1.48); .5 | 0.94 (0.38-2.28); .9 | 11 | 5 | 0.78 (0.49-1.24); .3 | 0.87 (0.48-1.57); .6 |
| Outcome at 5 y | ||||||||
| CIR | 48 | 39 | 0.75 (0.57-0.98); .03 | 0.75 (0.53-1.07); .11 | 50 | 30 | 0.78 (0.64-0.94); .01 | 0.80 (0.64-1.00); .05 |
| RFS | 35 | 48 | 0.74 (0.59-0.93); .008 | 0.71 (0.52-0.97); .03 | 35 | 60 | 0.77 (0.65-0.91); .003 | 0.78 (0.64-0.95); .01 |
| OS | 37 | 53 | 0.72 (0.58-0.89); .002 | 0.71 (0.52-0.96); .03 | 37 | 71 | 0.74 (0.63-0.87); .004 | 0.74 (0.61-0.91); .004 |
P values relating to TKD− versus TKD+ analysis are for the Mantel-Haenszel test for the initial response and the log-rank test for long-term outcomes. P values relating to TKD− versus TKD low versus TKD high analysis were obtained using logistic regression analysis. Adjusted results show results of multivariate analyses adjusted for significant variables in forward selection regression model.