Quantitation of anti-fVIII antibody in healthy donors, inhibitor-negative hemophilia A patients, and commercial inhibitor-negative human plasma with less than 1% fVIII activity
Anti-fVIII Ab, nM . | Healthy donor plasma, n = 150 . | Inhibitor-negative hemophilia A plasma . | |
---|---|---|---|
Hemophilia A subjects, n = 32 . | Commercial (< 1% fVIII activity), n = 7 . | ||
0.1-0.9 | 2 | 1 | 0 |
1-10 | 2 | 8 | 0 |
11-20 | 0 | 2 | 0 |
21-50 | 0 | 0 | 0 |
51-100 | 0 | 0 | 1 |
101-200 | 0 | 0 | 1 |
> 200 | 0 | 0 | 0 |
Anti-fVIII Ab–positive | 3% | 34% | 29% |
Anti-fVIII Ab, nM . | Healthy donor plasma, n = 150 . | Inhibitor-negative hemophilia A plasma . | |
---|---|---|---|
Hemophilia A subjects, n = 32 . | Commercial (< 1% fVIII activity), n = 7 . | ||
0.1-0.9 | 2 | 1 | 0 |
1-10 | 2 | 8 | 0 |
11-20 | 0 | 2 | 0 |
21-50 | 0 | 0 | 0 |
51-100 | 0 | 0 | 1 |
101-200 | 0 | 0 | 1 |
> 200 | 0 | 0 | 0 |
Anti-fVIII Ab–positive | 3% | 34% | 29% |