Primary diseases and therapy of patients with secondary MDS/tAML
| Primary disease . | No. of patients, n=257 . |
|---|---|
| Hematopoietic malignancies | 108 |
| Acute lymphocytic leukemia/acute myeloid leukemia* | 12/6 |
| Chronic lymphocytic leukemia/chronic myeloid leukemia | 4/2 |
| Hodgkin/non-Hodgkin lymphoma | 37/40 |
| Multiple myeloma | 7 |
| Other hematopoietic disorders | 75 |
| Aplastic anemia | 50 |
| Polycythemia vera/essential thrombocythemia | 13/6 |
| Fanconi anemia/idiopathic neutropenia | 3/3 |
| Solid tumors | 54 |
| Carcinoma | 48 |
| Breast | 27 |
| Cervix | 7 |
| Colon | 5 |
| Testicular | 3 |
| Thyroid | 2 |
| Other† | 4 |
| Sarcomas | 6 |
| Immunologic disorders | 20 |
| Arthritis | 4 |
| Vasculitis | 4 |
| Crohn disease | 3 |
| Lupus erythematosus | 2 |
| Multiple sclerosis | 2 |
| Other‡ | 4 |
| Treatment of primary disease | |
| Chemotherapy alone | 88 |
| Chemoradiotherapy | 68 |
| Irradiation | 4 |
| HCT autologous | 26 |
| HCT allogeneic | 6 |
| Immunosuppressive therapy | 57 |
| Other§ | 9 |
| Primary disease . | No. of patients, n=257 . |
|---|---|
| Hematopoietic malignancies | 108 |
| Acute lymphocytic leukemia/acute myeloid leukemia* | 12/6 |
| Chronic lymphocytic leukemia/chronic myeloid leukemia | 4/2 |
| Hodgkin/non-Hodgkin lymphoma | 37/40 |
| Multiple myeloma | 7 |
| Other hematopoietic disorders | 75 |
| Aplastic anemia | 50 |
| Polycythemia vera/essential thrombocythemia | 13/6 |
| Fanconi anemia/idiopathic neutropenia | 3/3 |
| Solid tumors | 54 |
| Carcinoma | 48 |
| Breast | 27 |
| Cervix | 7 |
| Colon | 5 |
| Testicular | 3 |
| Thyroid | 2 |
| Other† | 4 |
| Sarcomas | 6 |
| Immunologic disorders | 20 |
| Arthritis | 4 |
| Vasculitis | 4 |
| Crohn disease | 3 |
| Lupus erythematosus | 2 |
| Multiple sclerosis | 2 |
| Other‡ | 4 |
| Treatment of primary disease | |
| Chemotherapy alone | 88 |
| Chemoradiotherapy | 68 |
| Irradiation | 4 |
| HCT autologous | 26 |
| HCT allogeneic | 6 |
| Immunosuppressive therapy | 57 |
| Other§ | 9 |
HCT indicates hematopoietic cell transplantation.
In the 6 patients with the original diagnosis of AML, the secondary MDS/tAML showed an FAB subtype, karyotype, or both, different from the original disease.
Bladder cancer, ovarian cancer, renal cell cancer, or thymoma.
Hemolytic anemia, Shwachman-Diamond syndrome, Wegener granulomatosis, or X-linked agammaglobulinemia.
Iodine-131 or kidney transplantation.