CI values of ABT-737 at concentrations applied in combination with L-ASP, vincristine, and dexamethasone in ALL cell lines
| Drugs . | ABT-737, μM . | Cell lines . | ||||||
|---|---|---|---|---|---|---|---|---|
| CEM . | COG-LL-317 . | MOLT-3 . | MOLT-4 . | RS4-11 . | NALM-6 . | COG-LL-319 . | ||
| L-ASP, IU/mL | ||||||||
| 0.1 | 0.5 | 0.27 | 0.24 | 0.12 | 0.23 | 0.10 | 0.70 | 0.37 |
| 0.25 | 1.25 | 0.23 | 0.25 | 0.18 | 0.19 | 0.11 | 0.60 | 0.36 |
| 0.5 | 2.5 | 0.17 | 0.23 | 0.31 | 0.21 | 0.10 | 0.48 | 0.26 |
| 1.0 | 5 | 0.20 | 0.29 | 0.56 | 0.42 | 0.21 | 0.31 | 0.23 |
| Mean | — | 0.22 | 0.25 | 0.29 | 0.26 | 0.13 | 0.52 | 0.31 |
| VCR, ng/mL | ||||||||
| 5 | 0.5 | 0.04 | 0.13 | 0.42 | 0.42 | 0.08 | 0.86 | 0.52 |
| 12.5 | 1.25 | 0.08 | 0.10 | 0.27 | 0.35 | 0.15 | 0.93 | 0.40 |
| 25 | 2.5 | 0.10 | 0.07 | 0.53 | 0.59 | 0.19 | 0.67 | 0.28 |
| 50 | 5 | 0.15 | 0.09 | 1.06 | 1.42 | 0.30 | 1.21 | 0.37 |
| Mean | — | 0.09 | 0.10 | 0.57 | 0.70 | 0.18 | 0.92 | 0.39 |
| Dex, nM | ||||||||
| 50 | 0.5 | 0.23 | 0.17 | 0.83 | 0.65 | 0.21 | 0.33 | 0.46 |
| 125 | 1.25 | 0.21 | 0.32 | 0.88 | 0.86 | 0.41 | 0.37 | 0.55 |
| 250 | 2.5 | 0.26 | 0.54 | 0.65 | 0.70 | 0.52 | 0.45 | 0.72 |
| 500 | 5 | 0.34 | 0.60 | 0.89 | 0.62 | 0.75 | 0.44 | 1.13 |
| Mean | — | 0.26 | 0.41 | 0.81 | 0.71 | 0.47 | 0.40 | 0.72 |
| Drugs . | ABT-737, μM . | Cell lines . | ||||||
|---|---|---|---|---|---|---|---|---|
| CEM . | COG-LL-317 . | MOLT-3 . | MOLT-4 . | RS4-11 . | NALM-6 . | COG-LL-319 . | ||
| L-ASP, IU/mL | ||||||||
| 0.1 | 0.5 | 0.27 | 0.24 | 0.12 | 0.23 | 0.10 | 0.70 | 0.37 |
| 0.25 | 1.25 | 0.23 | 0.25 | 0.18 | 0.19 | 0.11 | 0.60 | 0.36 |
| 0.5 | 2.5 | 0.17 | 0.23 | 0.31 | 0.21 | 0.10 | 0.48 | 0.26 |
| 1.0 | 5 | 0.20 | 0.29 | 0.56 | 0.42 | 0.21 | 0.31 | 0.23 |
| Mean | — | 0.22 | 0.25 | 0.29 | 0.26 | 0.13 | 0.52 | 0.31 |
| VCR, ng/mL | ||||||||
| 5 | 0.5 | 0.04 | 0.13 | 0.42 | 0.42 | 0.08 | 0.86 | 0.52 |
| 12.5 | 1.25 | 0.08 | 0.10 | 0.27 | 0.35 | 0.15 | 0.93 | 0.40 |
| 25 | 2.5 | 0.10 | 0.07 | 0.53 | 0.59 | 0.19 | 0.67 | 0.28 |
| 50 | 5 | 0.15 | 0.09 | 1.06 | 1.42 | 0.30 | 1.21 | 0.37 |
| Mean | — | 0.09 | 0.10 | 0.57 | 0.70 | 0.18 | 0.92 | 0.39 |
| Dex, nM | ||||||||
| 50 | 0.5 | 0.23 | 0.17 | 0.83 | 0.65 | 0.21 | 0.33 | 0.46 |
| 125 | 1.25 | 0.21 | 0.32 | 0.88 | 0.86 | 0.41 | 0.37 | 0.55 |
| 250 | 2.5 | 0.26 | 0.54 | 0.65 | 0.70 | 0.52 | 0.45 | 0.72 |
| 500 | 5 | 0.34 | 0.60 | 0.89 | 0.62 | 0.75 | 0.44 | 1.13 |
| Mean | — | 0.26 | 0.41 | 0.81 | 0.71 | 0.47 | 0.40 | 0.72 |
A CI less than 0.9 indicates synergism; 0.1, very strong synergism; 0.1 to 0.3, strong synergism; 0.3 to 0.7, synergism; 0.7 to 0.85, moderate synergism; 0.85 to 0.9, slight synergism; 0.9 to 1.10, additive; and more than 1.10, antagonism.
— indicates not applicable.