Grading of dermal fibrosis in systemic sclerosis
| Dermal fibrosis grade . | Description . |
|---|---|
| 0 | No homogenization but there may be atrophic, thin straightened collagen bundles with increased amounts of interstitial ground substance |
| 1 | Less than 25% sclerosis with residual foci; some residual straightening or eosinophilic collagen bundles may be present |
| 2 | Focal sclerosis—less than 50% overall |
| 3 | Incomplete homogenization with spaces between the collagen bundles with 50% to 75% sclerotic change |
| 4 | Pandermal sclerosis without obvious expansion of the lower reticular dermis with some sparing of perieccrine adipose tissue |
| 5 | Pandermal sclerosis with homogenization from the papillary to the reticular dermis; includes obvious widening of the reticular dermis below the eccrine coils with extension into the hypodermis and formation of fibrous septa |
| Dermal fibrosis grade . | Description . |
|---|---|
| 0 | No homogenization but there may be atrophic, thin straightened collagen bundles with increased amounts of interstitial ground substance |
| 1 | Less than 25% sclerosis with residual foci; some residual straightening or eosinophilic collagen bundles may be present |
| 2 | Focal sclerosis—less than 50% overall |
| 3 | Incomplete homogenization with spaces between the collagen bundles with 50% to 75% sclerotic change |
| 4 | Pandermal sclerosis without obvious expansion of the lower reticular dermis with some sparing of perieccrine adipose tissue |
| 5 | Pandermal sclerosis with homogenization from the papillary to the reticular dermis; includes obvious widening of the reticular dermis below the eccrine coils with extension into the hypodermis and formation of fibrous septa |