Table 1 Characteristics of Down syndrome... | American Society of Hematology

Table 1

Characteristics of Down syndrome infants and incidence of GATA1 mutations

	Wild-type GATA1	Mutated GATA1	P
n	563	22	—
Sex, no.
Male	284	15	—
Female	279	7	.10†
Race, no.
White	439	20	—
African American	97	1	.15‡
Asian	24	1	1.00‡
Unknown	3	0	—
Hispanic status, no.
Hispanic, any race	110	9	—
Non-Hispanic, any race	409	12	.02†
Non-Hispanic white*	313	11	.06†
Non-Hispanic African American*	72	0	.02‡
Unknown	44	1	—
Mean age of mother, y	33.0	34.5	.31§
Developed AMKL, no.
Yes	0	2‖	—
No	563	20	.001‡

	Wild-type GATA1	Mutated GATA1	P
n	563	22	—
Sex, no.
Male	284	15	—
Female	279	7	.10†
Race, no.
White	439	20	—
African American	97	1	.15‡
Asian	24	1	1.00‡
Unknown	3	0	—
Hispanic status, no.
Hispanic, any race	110	9	—
Non-Hispanic, any race	409	12	.02†
Non-Hispanic white*	313	11	.06†
Non-Hispanic African American*	72	0	.02‡
Unknown	44	1	—
Mean age of mother, y	33.0	34.5	.31§
Developed AMKL, no.
Yes	0	2‖	—
No	563	20	.001‡

— indicates not applicable.

Compared with those with a Hispanic ethnicity with any race.

χ² test.

Fisher exact test.

ANOVA test.

One patient developed leukemia of unspecified phenotype.