Table 1
Physical properties and biochemical parameters used in numerical simulation
| Property | Value | Reference |
|---|---|---|
| Density of whole blood | 1060 kg/m3 | Goldsmith and Turitto23 |
| Viscosity of whole blood | 0.004 Pa s | Goldsmith and Turitto23 |
| Diffusivity of thrombin | 4.16×10−11 m2/s | Hubbell and McIntire24 |
| Thrombin flux | 7.7×10−10 U/platelets-s | Hubbell and McIntire24 |
| First-order ATIII inhibition | 0.035 1/s | Hockin et al25 |
| Property | Value | Reference |
|---|---|---|
| Density of whole blood | 1060 kg/m3 | Goldsmith and Turitto23 |
| Viscosity of whole blood | 0.004 Pa s | Goldsmith and Turitto23 |
| Diffusivity of thrombin | 4.16×10−11 m2/s | Hubbell and McIntire24 |
| Thrombin flux | 7.7×10−10 U/platelets-s | Hubbell and McIntire24 |
| First-order ATIII inhibition | 0.035 1/s | Hockin et al25 |
Boundary conditions are as follows for thrombin: chamber inlet: Cin = 0; chamber outlet: Jout = vy(z)Cout(x,y,z); walls: 
C=0; and microspots: JThrombin=1.11×10−10 mol/m2-s.