Mean and percentage difference in PBMC supernatant cytokine levels (pg/mL) between young adult Hodgkin lymphoma (YAHL) case-twins and matched controls, and among their unaffected cotwins and matched controls
| Cytokines . | YAHL-affected case-twins vs controls . | Unaffected cotwins vs controls . | ||||||
|---|---|---|---|---|---|---|---|---|
| No. of pairs . | Mean*† difference, pg/mL . | % difference . | P‡ . | No. of pairs . | Mean†§ difference, pg/mL . | % difference . | P‡ . | |
| All | ||||||||
| Interleukin-2 (IL-2) | 83 | 14.0 | 47.9 | .049 | 80 | 3.1 | 11.8 | .57 |
| Interleukin-12 (IL-12) | 63 | −0.9 | −60.6 | .002 | 62 | −1.7 | −49.0 | .04 |
| Interferon-γ (IFN-γ) | 74 | 6.6 | 20.2 | .41 | 70 | −5.1 | −13.7 | .58 |
| Monozygotic (MZ) | ||||||||
| Interleukin-2 (IL-2) | 55 | 8.2 | 23.2 | .42 | 51 | 2.7 | 8.3 | .76 |
| Interleukin-12 (IL-12) | 43 | −0.9 | −51.1 | .02 | 39 | −0.4 | −23.0 | .47 |
| Interferon-γ (IFN-γ) | 46 | −0.1 | −0.4 | .99 | 41 | −10.5 | −25.4 | .42 |
| Dizygotic (DZ) | ||||||||
| Interleukin-2 (IL-2) | 28 | 22.5 | 98.3 | .02 | 29 | 0.7 | 3.5 | .90 |
| Interleukin-12 (IL-12) | 20 | −1.4 | −74.3 | .06 | 23 | −1.8 | −56.1 | .17 |
| Interferon-γ (IFN-γ) | 28 | 32.9 | 63.3 | .25 | 29 | −4.9 | −14.6 | .70 |
| Cytokines . | YAHL-affected case-twins vs controls . | Unaffected cotwins vs controls . | ||||||
|---|---|---|---|---|---|---|---|---|
| No. of pairs . | Mean*† difference, pg/mL . | % difference . | P‡ . | No. of pairs . | Mean†§ difference, pg/mL . | % difference . | P‡ . | |
| All | ||||||||
| Interleukin-2 (IL-2) | 83 | 14.0 | 47.9 | .049 | 80 | 3.1 | 11.8 | .57 |
| Interleukin-12 (IL-12) | 63 | −0.9 | −60.6 | .002 | 62 | −1.7 | −49.0 | .04 |
| Interferon-γ (IFN-γ) | 74 | 6.6 | 20.2 | .41 | 70 | −5.1 | −13.7 | .58 |
| Monozygotic (MZ) | ||||||||
| Interleukin-2 (IL-2) | 55 | 8.2 | 23.2 | .42 | 51 | 2.7 | 8.3 | .76 |
| Interleukin-12 (IL-12) | 43 | −0.9 | −51.1 | .02 | 39 | −0.4 | −23.0 | .47 |
| Interferon-γ (IFN-γ) | 46 | −0.1 | −0.4 | .99 | 41 | −10.5 | −25.4 | .42 |
| Dizygotic (DZ) | ||||||||
| Interleukin-2 (IL-2) | 28 | 22.5 | 98.3 | .02 | 29 | 0.7 | 3.5 | .90 |
| Interleukin-12 (IL-12) | 20 | −1.4 | −74.3 | .06 | 23 | −1.8 | −56.1 | .17 |
| Interferon-γ (IFN-γ) | 28 | 32.9 | 63.3 | .25 | 29 | −4.9 | −14.6 | .70 |
Geometric mean difference of young adult HL-affected case-twins' log-transformed cytokine levels minus those of their matched controls.
Adjusted for sex, age (categoric: ≤30, 31-40, 41-50, and 51-60 years), and ELISA plate.
P value ANOVA (SAS GLM procedure).
Geometric mean difference of unaffected cotwins' log-transformed cytokine levels minus those of their matched controls.