Table 1

Quantification of ultrastructural features of VAMP-8+/+ and VAMP-8−/− BMMCs

Mice and experimentsGranule size, % small granulesNo. of SGs/cell, mean plus or minus SEMNo. of immature* SGs/cell, mean plus or minus SEM
VAMP-8 WT 
    Exp 1, n = 47 60 43.4 ± 3.0 9.3 ± 1.2 
    Exp 2, n = 25 65 22.3 ± 2.5 9.1 ± 2.3 
VAMP-8 deficient 
    Exp 1, n = 59 61 36.0 ± 3.0 5.8 ± 0.56 
    Exp 2, n = 42 59 22.6 ± 1.8 5.3 ± 1.00 
Mice and experimentsGranule size, % small granulesNo. of SGs/cell, mean plus or minus SEMNo. of immature* SGs/cell, mean plus or minus SEM
VAMP-8 WT 
    Exp 1, n = 47 60 43.4 ± 3.0 9.3 ± 1.2 
    Exp 2, n = 25 65 22.3 ± 2.5 9.1 ± 2.3 
VAMP-8 deficient 
    Exp 1, n = 59 61 36.0 ± 3.0 5.8 ± 0.56 
    Exp 2, n = 42 59 22.6 ± 1.8 5.3 ± 1.00 
*

Immature granules were defined as electron-lucent granules; mature granules were considered as those filled with electron-dense material.

Statistically significant differences (P < .05).

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