Table 1

Predictive factors for abnormally high velocities (≥ 2m/sec) by univariable models

VariableStroke-free SS patients, n = 373Abnormal TCD n = 62
Normal TCD n = 311
OR (95% CI)P
EventsnEventsn
Male gender 193 32 62 161 311 1.04 (0.61-1.77) .89 
β-globin haplotypes 293  42  251   
    Car/Car 118 18  100  0.71 (0.38-1.33) .28 
    Ben/Ben 71 10  61  0.60 (0.28-1.30) .19 
    Sen/Sen 27  25  0.61 (0.20-1.87) .39 
    Others 77 12  65    
α-thalassemia 155/325* 12 50 143 275 0.29 (0.15-0.58) < .001 
G6PD deficiency 36/325* 11 55 25 270 2.45 (1.12-5.35) .024 
VariableStroke-free SS patients, n = 373Abnormal TCD n = 62
Normal TCD n = 311
OR (95% CI)P
EventsnEventsn
Male gender 193 32 62 161 311 1.04 (0.61-1.77) .89 
β-globin haplotypes 293  42  251   
    Car/Car 118 18  100  0.71 (0.38-1.33) .28 
    Ben/Ben 71 10  61  0.60 (0.28-1.30) .19 
    Sen/Sen 27  25  0.61 (0.20-1.87) .39 
    Others 77 12  65    
α-thalassemia 155/325* 12 50 143 275 0.29 (0.15-0.58) < .001 
G6PD deficiency 36/325* 11 55 25 270 2.45 (1.12-5.35) .024 
*

α gene study and G6PD were available in 325 of 373 patients.

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