Predictive factors for abnormally high velocities (≥ 2m/sec) by univariable models
Variable . | Stroke-free SS patients, n = 373 . | Abnormal TCD n = 62 . | Normal TCD n = 311 . | OR (95% CI) . | P . | ||
---|---|---|---|---|---|---|---|
Events . | n . | Events . | n . | ||||
Male gender | 193 | 32 | 62 | 161 | 311 | 1.04 (0.61-1.77) | .89 |
β-globin haplotypes | 293 | 42 | 251 | ||||
Car/Car | 118 | 18 | 100 | 0.71 (0.38-1.33) | .28 | ||
Ben/Ben | 71 | 10 | 61 | 0.60 (0.28-1.30) | .19 | ||
Sen/Sen | 27 | 2 | 25 | 0.61 (0.20-1.87) | .39 | ||
Others | 77 | 12 | 65 | ||||
α-thalassemia | 155/325* | 12 | 50 | 143 | 275 | 0.29 (0.15-0.58) | < .001 |
G6PD deficiency | 36/325* | 11 | 55 | 25 | 270 | 2.45 (1.12-5.35) | .024 |
Variable . | Stroke-free SS patients, n = 373 . | Abnormal TCD n = 62 . | Normal TCD n = 311 . | OR (95% CI) . | P . | ||
---|---|---|---|---|---|---|---|
Events . | n . | Events . | n . | ||||
Male gender | 193 | 32 | 62 | 161 | 311 | 1.04 (0.61-1.77) | .89 |
β-globin haplotypes | 293 | 42 | 251 | ||||
Car/Car | 118 | 18 | 100 | 0.71 (0.38-1.33) | .28 | ||
Ben/Ben | 71 | 10 | 61 | 0.60 (0.28-1.30) | .19 | ||
Sen/Sen | 27 | 2 | 25 | 0.61 (0.20-1.87) | .39 | ||
Others | 77 | 12 | 65 | ||||
α-thalassemia | 155/325* | 12 | 50 | 143 | 275 | 0.29 (0.15-0.58) | < .001 |
G6PD deficiency | 36/325* | 11 | 55 | 25 | 270 | 2.45 (1.12-5.35) | .024 |
α gene study and G6PD were available in 325 of 373 patients.