Autoimmune disease and risk of MM in white and black US male veterans
| . | Whites . | Blacks . | Combined . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| N . | RR* . | 95% CI . | N . | RR* . | 95% CI . | N . | RR* . | 95% CI . | |
| Total autoimmune disease | 256 | 1.14 | 1.00-1.31 | 106 | 1.15 | 0.94-1.42 | 362 | 1.15 | 1.02-1.28 |
| Autoantibodies detectable | 199 | 1.25 | 1.08-1.46 | 85 | 1.19 | 0.94-1.50 | 284 | 1.23 | 1.09-1.40 |
| Systemic involvement | 75 | 1.21 | 0.95-1.55 | 37 | 1.40 | 0.99-2.00 | 112 | 1.26 | 1.04-1.55 |
| Polymyositis/dermatomyositis | 3 | — | — | 3 | — | — | 6 | 2.29 | 1.03-5.09 |
| Rheumatoid arthritis | 63 | 1.10 | 0.85-1.43 | 31 | 1.34 | 0.91-1.98 | 94 | 1.17 | 0.94-1.45 |
| Systemic lupus erythematosus | 5 | 1.45 | 0.47-4.51 | 2 | — | — | 7 | 1.64 | 0.68-3.93 |
| Systemic sclerosis | 4 | — | — | 2 | — | — | 6 | 2.41 | 1.08-5.36 |
| Organ involvement | 132 | 1.30 | 1.09-1.56 | 51 | 1.07 | 0.80-1.43 | 183 | 1.23 | 1.05-1.43 |
| Amyotrophic lateral sclerosis | 6 | 1.25 | 0.52-2.99. | 2 | — | — | 8 | 1.18 | 0.56-2.47 |
| Autoimmune hemolytic anemia | 8 | 3.52 | 1.58-7.85 | 3 | — | — | 11 | 2.82 | 1.41-5.64 |
| Celiac disease | 3 | — | — | 2 | — | — | 5 | 2.07 | 0.86-4.98 |
| Chronic rheumatic heart disease | 51 | 1.06 | 0.80-1.40 | 27 | 1.11 | 0.74-1.65 | 78 | 1.07 | 0.85-1.35 |
| Discoid lupus erythematosus | 5 | 1.31 | 0.49-3.49 | 3 | — | — | 8 | 1.28 | 0.61-2.69 |
| Immune thrombocytopenic purpura | 8 | 1.00 | 0.41-2.40 | 3 | — | — | 11 | 1.08 | 0.54-2.16 |
| Myasthenia gravis | 4 | — | — | 2 | — | — | 6 | 2.09 | 0.94-4.66 |
| Pernicious anemia | 22 | 2.30 | 1.50-3.54 | 5 | 1.68 | 0.70-4.05 | 27 | 2.15 | 1.45-3.16 |
| Primary biliary cirrhosis | 8 | 1.52 | 0.76-3.04 | 2 | — | — | 10 | 1.18 | 0.61-2.28 |
| Autoantibodies not detectable | 75 | 0.95 | 0.75-1.20 | 32 | 1.25 | 0.87-1.81 | 107 | 1.02 | 0.84-1.25 |
| Ankylosing spondylitis | 16 | 1.82 | 1.12-2.98 | 9 | 4.23 | 2.20-8.16 | 25 | 2.29 | 1.55-3.40 |
| Hemorrhagic proctitis | 18 | 1.21 | 0.73-2.01 | 6 | 0.70 | 0.26-1.88 | 24 | 1.05 | 0.67-1.65 |
| Psoriasis | 29 | 0.85 | 0.59-1.23 | 5 | 0.92 | 0.38-2.22 | 34 | 0.86 | 0.61-1.21 |
| Sarcoidosis | 0 | — | — | 6 | 1.20 | 0.54-2.69 | 6 | 0.92 | 0.42-2.07 |
| Ulcerative colitis | 7 | 0.81 | 0.39-1.71 | 1 | — | — | 8 | 0.78 | 0.39-1.56 |
| . | Whites . | Blacks . | Combined . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| N . | RR* . | 95% CI . | N . | RR* . | 95% CI . | N . | RR* . | 95% CI . | |
| Total autoimmune disease | 256 | 1.14 | 1.00-1.31 | 106 | 1.15 | 0.94-1.42 | 362 | 1.15 | 1.02-1.28 |
| Autoantibodies detectable | 199 | 1.25 | 1.08-1.46 | 85 | 1.19 | 0.94-1.50 | 284 | 1.23 | 1.09-1.40 |
| Systemic involvement | 75 | 1.21 | 0.95-1.55 | 37 | 1.40 | 0.99-2.00 | 112 | 1.26 | 1.04-1.55 |
| Polymyositis/dermatomyositis | 3 | — | — | 3 | — | — | 6 | 2.29 | 1.03-5.09 |
| Rheumatoid arthritis | 63 | 1.10 | 0.85-1.43 | 31 | 1.34 | 0.91-1.98 | 94 | 1.17 | 0.94-1.45 |
| Systemic lupus erythematosus | 5 | 1.45 | 0.47-4.51 | 2 | — | — | 7 | 1.64 | 0.68-3.93 |
| Systemic sclerosis | 4 | — | — | 2 | — | — | 6 | 2.41 | 1.08-5.36 |
| Organ involvement | 132 | 1.30 | 1.09-1.56 | 51 | 1.07 | 0.80-1.43 | 183 | 1.23 | 1.05-1.43 |
| Amyotrophic lateral sclerosis | 6 | 1.25 | 0.52-2.99. | 2 | — | — | 8 | 1.18 | 0.56-2.47 |
| Autoimmune hemolytic anemia | 8 | 3.52 | 1.58-7.85 | 3 | — | — | 11 | 2.82 | 1.41-5.64 |
| Celiac disease | 3 | — | — | 2 | — | — | 5 | 2.07 | 0.86-4.98 |
| Chronic rheumatic heart disease | 51 | 1.06 | 0.80-1.40 | 27 | 1.11 | 0.74-1.65 | 78 | 1.07 | 0.85-1.35 |
| Discoid lupus erythematosus | 5 | 1.31 | 0.49-3.49 | 3 | — | — | 8 | 1.28 | 0.61-2.69 |
| Immune thrombocytopenic purpura | 8 | 1.00 | 0.41-2.40 | 3 | — | — | 11 | 1.08 | 0.54-2.16 |
| Myasthenia gravis | 4 | — | — | 2 | — | — | 6 | 2.09 | 0.94-4.66 |
| Pernicious anemia | 22 | 2.30 | 1.50-3.54 | 5 | 1.68 | 0.70-4.05 | 27 | 2.15 | 1.45-3.16 |
| Primary biliary cirrhosis | 8 | 1.52 | 0.76-3.04 | 2 | — | — | 10 | 1.18 | 0.61-2.28 |
| Autoantibodies not detectable | 75 | 0.95 | 0.75-1.20 | 32 | 1.25 | 0.87-1.81 | 107 | 1.02 | 0.84-1.25 |
| Ankylosing spondylitis | 16 | 1.82 | 1.12-2.98 | 9 | 4.23 | 2.20-8.16 | 25 | 2.29 | 1.55-3.40 |
| Hemorrhagic proctitis | 18 | 1.21 | 0.73-2.01 | 6 | 0.70 | 0.26-1.88 | 24 | 1.05 | 0.67-1.65 |
| Psoriasis | 29 | 0.85 | 0.59-1.23 | 5 | 0.92 | 0.38-2.22 | 34 | 0.86 | 0.61-1.21 |
| Sarcoidosis | 0 | — | — | 6 | 1.20 | 0.54-2.69 | 6 | 0.92 | 0.42-2.07 |
| Ulcerative colitis | 7 | 0.81 | 0.39-1.71 | 1 | — | — | 8 | 0.78 | 0.39-1.56 |
— indicates RR and CI not calculated due to small numbers.
RR adjusted for visits, attained age, calendar time, and latency (combined also adjusted for race).