Cytokine concentrations in FL compared with FH
| Cytokine . | FH cytokine concentrations (N = 23)* . | FL cytokine concentrations, all grades (N = 50)* . | P† . | ||||
|---|---|---|---|---|---|---|---|
| Median . | SD . | Range . | Median . | SD . | Range . | ||
| IFN-γ | 1.05 | 1.15 | 0.2-4.4 | 0.40 | 0.51 | 0.12-3.07 | < .001 |
| IL-1β | 68.68 | 35.59 | 18.86-191.26 | 1.74 | 3.22 | 0.19-11.95 | < .001 |
| IL-2 | 3.90 | 4.75 | 1.31-18.93 | 2.28 | 2.9 | 0.31-13.89 | .006 |
| IL-4 | 1.19 | 1.48 | 0.22-6.21 | 5.08 | 9.39 | 0.25-38.6 | < .001 |
| IL-5 | 0.72 | 1.05 | 0.21-3.70 | 0.26 | 0.14 | 0.11-0.78 | < .001 |
| IL-8 | 217.33 | 358.99 | 46.36-1509.9 | 0.57 | 49.71 | 0.24-352.28 | < .001 |
| IL-10 | 0.74 | 1.74 | 0.23-5.81 | 0.28 | 0.74 | 0.12-5.25 | < .001 |
| IL-12 p70 | 1.85 | 6.15 | 0.23-24.51 | 0.38 | 1.23 | 0.15-8.26 | < .001 |
| IL-13 | 11.74 | 13.61 | 2.48-58.1 | 0.58 | 6.73 | 0.19-40.99 | < .001 |
| TNF-α | 34.17 | 23.49 | 0.33-97.39 | 9.74 | 12.06 | 1.23-50.8 | < .001 |
| Cytokine . | FH cytokine concentrations (N = 23)* . | FL cytokine concentrations, all grades (N = 50)* . | P† . | ||||
|---|---|---|---|---|---|---|---|
| Median . | SD . | Range . | Median . | SD . | Range . | ||
| IFN-γ | 1.05 | 1.15 | 0.2-4.4 | 0.40 | 0.51 | 0.12-3.07 | < .001 |
| IL-1β | 68.68 | 35.59 | 18.86-191.26 | 1.74 | 3.22 | 0.19-11.95 | < .001 |
| IL-2 | 3.90 | 4.75 | 1.31-18.93 | 2.28 | 2.9 | 0.31-13.89 | .006 |
| IL-4 | 1.19 | 1.48 | 0.22-6.21 | 5.08 | 9.39 | 0.25-38.6 | < .001 |
| IL-5 | 0.72 | 1.05 | 0.21-3.70 | 0.26 | 0.14 | 0.11-0.78 | < .001 |
| IL-8 | 217.33 | 358.99 | 46.36-1509.9 | 0.57 | 49.71 | 0.24-352.28 | < .001 |
| IL-10 | 0.74 | 1.74 | 0.23-5.81 | 0.28 | 0.74 | 0.12-5.25 | < .001 |
| IL-12 p70 | 1.85 | 6.15 | 0.23-24.51 | 0.38 | 1.23 | 0.15-8.26 | < .001 |
| IL-13 | 11.74 | 13.61 | 2.48-58.1 | 0.58 | 6.73 | 0.19-40.99 | < .001 |
| TNF-α | 34.17 | 23.49 | 0.33-97.39 | 9.74 | 12.06 | 1.23-50.8 | < .001 |
Median cytokine concentrations in follicular lymphoma (FL; N = 50) compared to follicular hyperplasia (FH; N = 20) determined using a multiplex sandwich immunoassay system (“Methods”), reported as pg/mg of total protein in LN tissue lysates. Standard deviations of the mean (SD) and ranges are reported in adjacent columns.
P values for comparisons between FL, all grades, and FH determined using the Mann-Whitney rank test with significance set at P = .01 due to multiple comparisons.