Cytokine concentrations of FL by grade
| Cytokine . | FL grade 1 cytokine concentrations (N = 20)* . | FL grade 2 cytokine concentrations (N = 18)* . | FL grade 3 cytokine concentrations (N = 12)* . | P† . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Median . | SD . | Range . | Median . | SD . | Range . | Median . | SD . | Range . | ||
| IFN-γ | 0.33 | 0.27 | 0.14-1.05 | 0.38 | 0.21 | 0.12-1.00 | 0.75 | 0.83 | 0.29-3.07 | .009 |
| IL-1β | 0.90 | 2.48 | 0.37-10.59 | 2.95 | 3.21 | 0.29-9.88 | 2.63 | 4.07 | 0.19-11.95 | .084 |
| IL-2 | 1.57 | 1.66 | 0.46-7.38 | 2.27 | 2.16 | 0.97-9.02 | 3.29 | 4.34 | 0.31-13.89 | .053 |
| IL-4 | 6.30 | 6.70 | 1.18-26.20 | 6.43 | 7.40 | 0.29-32.08 | 2.56 | 14.83 | 0.25-38.60 | .8 |
| IL-5 | 0.27 | 0.16 | 0.12-0.78 | 0.26 | 0.11 | 0.11-0.52 | 0.21 | 0.17 | 0.12-0.62 | .83 |
| IL-8 | 0.54 | 2.96 | 0.3-11.39 | 0.53 | 82.87 | 0.24-352.28 | 1.74 | 7.77 | 0.25-24.15 | .11 |
| IL-10 | 0.29 | 0.19 | 0.12-0.83 | 0.28 | 0.12 | 0.12-0.57 | 0.26 | 1.48 | 0.14-5.25 | .94 |
| IL-12 p70 | 0.41 | 0.35 | 0.21-1.41 | 0.38 | 0.22 | 0.27-1.14 | 0.40 | 2.43 | 0.15-8.26 | .72 |
| IL-13 | 0.45 | 1.44 | 0.19-5.75 | 0.53 | 9.51 | 0.21-40.99 | 1.41 | 7.08 | 0.25-21.87 | .058 |
| TNF-α | 9.33 | 5.36 | 1.23-24.71 | 9.24 | 11.05 | 1.85-47.05 | 15.39 | 17.17 | 3.57-50.80 | .12 |
| Cytokine . | FL grade 1 cytokine concentrations (N = 20)* . | FL grade 2 cytokine concentrations (N = 18)* . | FL grade 3 cytokine concentrations (N = 12)* . | P† . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Median . | SD . | Range . | Median . | SD . | Range . | Median . | SD . | Range . | ||
| IFN-γ | 0.33 | 0.27 | 0.14-1.05 | 0.38 | 0.21 | 0.12-1.00 | 0.75 | 0.83 | 0.29-3.07 | .009 |
| IL-1β | 0.90 | 2.48 | 0.37-10.59 | 2.95 | 3.21 | 0.29-9.88 | 2.63 | 4.07 | 0.19-11.95 | .084 |
| IL-2 | 1.57 | 1.66 | 0.46-7.38 | 2.27 | 2.16 | 0.97-9.02 | 3.29 | 4.34 | 0.31-13.89 | .053 |
| IL-4 | 6.30 | 6.70 | 1.18-26.20 | 6.43 | 7.40 | 0.29-32.08 | 2.56 | 14.83 | 0.25-38.60 | .8 |
| IL-5 | 0.27 | 0.16 | 0.12-0.78 | 0.26 | 0.11 | 0.11-0.52 | 0.21 | 0.17 | 0.12-0.62 | .83 |
| IL-8 | 0.54 | 2.96 | 0.3-11.39 | 0.53 | 82.87 | 0.24-352.28 | 1.74 | 7.77 | 0.25-24.15 | .11 |
| IL-10 | 0.29 | 0.19 | 0.12-0.83 | 0.28 | 0.12 | 0.12-0.57 | 0.26 | 1.48 | 0.14-5.25 | .94 |
| IL-12 p70 | 0.41 | 0.35 | 0.21-1.41 | 0.38 | 0.22 | 0.27-1.14 | 0.40 | 2.43 | 0.15-8.26 | .72 |
| IL-13 | 0.45 | 1.44 | 0.19-5.75 | 0.53 | 9.51 | 0.21-40.99 | 1.41 | 7.08 | 0.25-21.87 | .058 |
| TNF-α | 9.33 | 5.36 | 1.23-24.71 | 9.24 | 11.05 | 1.85-47.05 | 15.39 | 17.17 | 3.57-50.80 | .12 |
Median cytokine concentrations in follicular lymphoma (N = 50) by histologic grade determined using a multiplex sandwich immunoassay system (“Methods”), reported as pg/mg of total protein in LN tissue lysates. Standard deviations of the mean (SD) and ranges are reported in adjacent columns.
P values for comparisons among grades of FL determined using the Kruskal-Wallis rank test with significance at P = .01 due to multiple comparisons.