Other hematologic and chemistry parameters in vehicle- and FG-2216–treated animals
| Laboratory parameter, reference range . | Baseline . | FG-2216, 60 mg/kg . | FG-2216, 60 mg/kg + phlebotomy . | Recovery . |
|---|---|---|---|---|
| Leukocyte count, 3.8 to 12.2 × cells/L | 7.7 ± 2.3 | 6.0 ± 2.4 | 5.9 ± 2.0 | 7.8 ± 2.6 |
| 7.1 ± 2.3 | 5.6 ± 1.4 | 5.5 ± 1.2 | 6.9 ± 1.9 | |
| Red cell count, 3.1-8.6 × 1012/μL | 5.1 ± 0.2 | 6.0 ± 0.7 | 5.6 ± 0.2 | 5.5 ± 0.3 |
| 4.9 ± 0.2 | 4.7 ± 0.5 | 4.4 ± 0.2 | 5.4 ± 0.1 | |
| Hematocrit, 0.32-0.50 | 0.37 ± 0.02 | 0.44 ± 0.06 | 0.43 ± 0.03 | 0.41 ± 0.03 |
| 0.35 ± 0.02 | 0.35 ± 0.03 | 0.34 ± 0.02 | 0.40 ± 0.01 | |
| Mean corpuscular volume*, fL | 72 ± 1.7 | 74 ± 1.7 | 79 ± 2 | 75 ± 2.2 |
| 72 ± 0.4 | 74 ± 1.5 | 76 ± 0.5 | 74 ± 0.3 | |
| Platelet count, 268-507 cells/L | 377 ± 51 | 407 ± 59 | 449 ± 75 | 386 ± 55 |
| 373 ± 33 | 391 ± 64 | 385 ± 85 | 405 ± 45 | |
| Glucose level†, 1.39-5.27 mmol/L | 3.44 ± 0.56 | 2.66 ± 0.61 | 2.5 ± 0.28 | 3.22 ± 0.33 |
| 3.22 ± 0.5 | 3.39 ± 0.33 | 3.55 ± 0.39 | 3.66 ± 0.72 | |
| LDH level, 393-2440 units/L | 1205 ± 522 | 1783 ± 467 | 1589 ± 392 | 1045 ± 478 |
| 819 ± 0 | 1239 ± 319 | 1075 ± 376 | 884 ± 220 | |
| AST level, 23-81 units/L | 50 ± 9 | 50 ± 6 | 54 ± 5 | 50 ± 9 |
| 36 ± 3 | 33 ± 3 | 39 ± 10 | 38 ± 6 | |
| ALT level, 18-59 units/L | 51 ± 4 | 54 ± 19 | 44 ± 1 | 46 ± 9 |
| 38 ± 1 | 33 ± 3 | 37 ± 2 | 40 ± 5 | |
| Albumin level, 2.5-5.6 g/dL | 40 ± 3 | 33 ± 4 | 32 ± 3 | 30 ± 3 |
| 38 ± 2 | 33 ± 1 | 31 ± 1 | 33 ± 2 | |
| Creatinine level‡, 17.7-106 μmol/L | 79.6 ± 8.8 | 70.7 ± 8.8 | 70.7 ± 8.8 | 70.7 ± 8.8 |
| 79.6 ± 8.8 | 79.6 ± 8.8 | 79.6 ± 8.8 | 88.4 ± 17.7 |
| Laboratory parameter, reference range . | Baseline . | FG-2216, 60 mg/kg . | FG-2216, 60 mg/kg + phlebotomy . | Recovery . |
|---|---|---|---|---|
| Leukocyte count, 3.8 to 12.2 × cells/L | 7.7 ± 2.3 | 6.0 ± 2.4 | 5.9 ± 2.0 | 7.8 ± 2.6 |
| 7.1 ± 2.3 | 5.6 ± 1.4 | 5.5 ± 1.2 | 6.9 ± 1.9 | |
| Red cell count, 3.1-8.6 × 1012/μL | 5.1 ± 0.2 | 6.0 ± 0.7 | 5.6 ± 0.2 | 5.5 ± 0.3 |
| 4.9 ± 0.2 | 4.7 ± 0.5 | 4.4 ± 0.2 | 5.4 ± 0.1 | |
| Hematocrit, 0.32-0.50 | 0.37 ± 0.02 | 0.44 ± 0.06 | 0.43 ± 0.03 | 0.41 ± 0.03 |
| 0.35 ± 0.02 | 0.35 ± 0.03 | 0.34 ± 0.02 | 0.40 ± 0.01 | |
| Mean corpuscular volume*, fL | 72 ± 1.7 | 74 ± 1.7 | 79 ± 2 | 75 ± 2.2 |
| 72 ± 0.4 | 74 ± 1.5 | 76 ± 0.5 | 74 ± 0.3 | |
| Platelet count, 268-507 cells/L | 377 ± 51 | 407 ± 59 | 449 ± 75 | 386 ± 55 |
| 373 ± 33 | 391 ± 64 | 385 ± 85 | 405 ± 45 | |
| Glucose level†, 1.39-5.27 mmol/L | 3.44 ± 0.56 | 2.66 ± 0.61 | 2.5 ± 0.28 | 3.22 ± 0.33 |
| 3.22 ± 0.5 | 3.39 ± 0.33 | 3.55 ± 0.39 | 3.66 ± 0.72 | |
| LDH level, 393-2440 units/L | 1205 ± 522 | 1783 ± 467 | 1589 ± 392 | 1045 ± 478 |
| 819 ± 0 | 1239 ± 319 | 1075 ± 376 | 884 ± 220 | |
| AST level, 23-81 units/L | 50 ± 9 | 50 ± 6 | 54 ± 5 | 50 ± 9 |
| 36 ± 3 | 33 ± 3 | 39 ± 10 | 38 ± 6 | |
| ALT level, 18-59 units/L | 51 ± 4 | 54 ± 19 | 44 ± 1 | 46 ± 9 |
| 38 ± 1 | 33 ± 3 | 37 ± 2 | 40 ± 5 | |
| Albumin level, 2.5-5.6 g/dL | 40 ± 3 | 33 ± 4 | 32 ± 3 | 30 ± 3 |
| 38 ± 2 | 33 ± 1 | 31 ± 1 | 33 ± 2 | |
| Creatinine level‡, 17.7-106 μmol/L | 79.6 ± 8.8 | 70.7 ± 8.8 | 70.7 ± 8.8 | 70.7 ± 8.8 |
| 79.6 ± 8.8 | 79.6 ± 8.8 | 79.6 ± 8.8 | 88.4 ± 17.7 |
Values for animals in the chronic intermittent dosing study, at baseline, at the end of each treatment, and after 2 weeks of recovery in the absence of drug are shown. The number of animals in the FG-2216–treated (italics) and nontreated (nonitalics) groups is 4 and 3, respectively.
LDH indicates lactate dehydrogenase.
Reference range not available in rhesus macaques.
To convert the units of glucose to mg/dL, divide each value by 0.0555.
To convert the units of creatinine to mg/dL, divide each value by 88.4.