Percentage reticulocytes, F+ reticulocytes, and F+ cells by flow cytometry
| Percentages . | Baseline . | 40 mg/kg . | 60 mg/kg . | 60 mg/kg + phlebotomy . |
|---|---|---|---|---|
| Reticulocytes | ||||
| FG-2216 treated | 0.7 ± 0.2 | 1.8 ± 1.1 | 2.4 ± 0.2 | 3.7 ± 0.5 |
| Not treated | 1.6 ± 0.8 | 1.9 ± 0.8 | 2.0 ± 1.2 | 4.8 ± 2.0 |
| F+ reticulocytes | ||||
| FG-2216 treated | 5.2 ± 1.0 | 5.6 ± 2.9 | 7.6 ± 4.5* | 8.9 ± 3.7† |
| Not treated | 0.6 ± 0.8 | 0 | 1.1 ± 1.5 | 3.0 ± 3.7 |
| F+ cells | ||||
| FG-2216 treated | 0.7 ± 0.2 | 1.8 ± 1.1 | 3.3 ± 1.7* | 5.0 ± 1.3† |
| Not treated | 0.2 ± 0.1 | 0.3 ± 0 | 0.4 ± 0.3 | 0.9 ± 0.5 |
| Percentages . | Baseline . | 40 mg/kg . | 60 mg/kg . | 60 mg/kg + phlebotomy . |
|---|---|---|---|---|
| Reticulocytes | ||||
| FG-2216 treated | 0.7 ± 0.2 | 1.8 ± 1.1 | 2.4 ± 0.2 | 3.7 ± 0.5 |
| Not treated | 1.6 ± 0.8 | 1.9 ± 0.8 | 2.0 ± 1.2 | 4.8 ± 2.0 |
| F+ reticulocytes | ||||
| FG-2216 treated | 5.2 ± 1.0 | 5.6 ± 2.9 | 7.6 ± 4.5* | 8.9 ± 3.7† |
| Not treated | 0.6 ± 0.8 | 0 | 1.1 ± 1.5 | 3.0 ± 3.7 |
| F+ cells | ||||
| FG-2216 treated | 0.7 ± 0.2 | 1.8 ± 1.1 | 3.3 ± 1.7* | 5.0 ± 1.3† |
| Not treated | 0.2 ± 0.1 | 0.3 ± 0 | 0.4 ± 0.3 | 0.9 ± 0.5 |
Values at the last 2 weeks of the treatment period were averaged. The actual mean percentages (%) and standard deviations among all animals in the same treatment cohort are shown: no drug control (n = 2), 40 mg/kg (n = 3), 60 mg/kg (n = 4), and 60 mg/kg with phlebotomy (n = 4).
P = .1 to .05.
P < .05 when compared with control animals.