Summary of experimental RRV infection studies
| Animal ID . | Virus infection . | CD4+ T-cell preinfection cells/μL . | CD4+ T-cell nadir, cells/μL . | CD20+ B-cell preinfection cells/μL . | CD20+ B-cell at peak, cells/μL . | Survival (days) after RRV infection . | Disease . |
|---|---|---|---|---|---|---|---|
| Cohort 1 | |||||||
| 18483 | SIVmac239/RRV17577 | 1697 | 422 | 899 | 2782 | 531 | RF, MCD |
| 18570 | SIVmac239/RRV17577 | 903 | 270 | 630 | 5543 | 286 | MCD, autoimmune hemolytic anemia |
| 19092 | RRV17577 | 1142 | 693 | 717 | 1246 | Alive | |
| 19286 | RRV17577 | 793 | 190 | 447 | 1686 | 1552 | B-cell lymphoma (liver) |
| Cohort 2 | |||||||
| 19095 | 2A:SIVmac239/RRV17577 | 902 | 1472 | 330 | 960 | 93 | Lymphadenopathy/cryptosporidium |
| 19105 | 2A:SIVmac239/RRV17577 | 788 | 287 | 251 | 1367 | 352 | Staphyloccocal infection in heart, splenomegaly/lymphadenopathy |
| 19185 | 2A:SIVmac239/RRV17577 | 1537 | 162 | 1103 | 1488 | 676 | Widespread B-cell lymphoma/MCD |
| 19182 | 2B:RRV17577/SIVmac239 | 1502 | 5 | 1174 | 2724 | 1135 | Chronic diarrhea, splenomegaly/lymphadenopathy |
| 19218 | 2B:RRV17577/SIVmac239 | 1531 | 93 | 495 | 2964 | 1119 | Splenomegaly/lymphadenopathy |
| Cohort 3 | |||||||
| 19455 | SIVmac239/RRV17577 #3 | 1792 | 188 | 2039 | 5859 | 1331 | MCD |
| 19490 | SIVmac239/RRV17577 #3 | 910 | 502 | 735 | 1449 | Alive | Lymphadenopathy |
| 21321 | SIVmac239/RRV17577 #3 | 2543 | 623 | 906 | 3092 | Alive | |
| 21491 | SIVmac239/RRV17577 #3 | 2196 | 1010 | 1760 | 4090 | 713 | Splenomegaly/lymphadenopathy |
| Cohort 4 | |||||||
| 19107 | SIVmac239/RRV17577 #7 | 1480 | 359 | 937 | 1793 | 680 | Lymphadenopathy |
| 19451 | SIVmac239/RRV17577 #7 | 592 | 99 | 308 | 1796 | 296 | Lymphadenopathy |
| 21520 | SIVmac239/RRV17577 #7 | 2525 | 598 | 1167 | 3870 | 887 | Splenomegaly |
| 21831 | SIVmac239/RRV17577 #7 | 2297 | 588 | 1665 | 2455 | 475 |
| Animal ID . | Virus infection . | CD4+ T-cell preinfection cells/μL . | CD4+ T-cell nadir, cells/μL . | CD20+ B-cell preinfection cells/μL . | CD20+ B-cell at peak, cells/μL . | Survival (days) after RRV infection . | Disease . |
|---|---|---|---|---|---|---|---|
| Cohort 1 | |||||||
| 18483 | SIVmac239/RRV17577 | 1697 | 422 | 899 | 2782 | 531 | RF, MCD |
| 18570 | SIVmac239/RRV17577 | 903 | 270 | 630 | 5543 | 286 | MCD, autoimmune hemolytic anemia |
| 19092 | RRV17577 | 1142 | 693 | 717 | 1246 | Alive | |
| 19286 | RRV17577 | 793 | 190 | 447 | 1686 | 1552 | B-cell lymphoma (liver) |
| Cohort 2 | |||||||
| 19095 | 2A:SIVmac239/RRV17577 | 902 | 1472 | 330 | 960 | 93 | Lymphadenopathy/cryptosporidium |
| 19105 | 2A:SIVmac239/RRV17577 | 788 | 287 | 251 | 1367 | 352 | Staphyloccocal infection in heart, splenomegaly/lymphadenopathy |
| 19185 | 2A:SIVmac239/RRV17577 | 1537 | 162 | 1103 | 1488 | 676 | Widespread B-cell lymphoma/MCD |
| 19182 | 2B:RRV17577/SIVmac239 | 1502 | 5 | 1174 | 2724 | 1135 | Chronic diarrhea, splenomegaly/lymphadenopathy |
| 19218 | 2B:RRV17577/SIVmac239 | 1531 | 93 | 495 | 2964 | 1119 | Splenomegaly/lymphadenopathy |
| Cohort 3 | |||||||
| 19455 | SIVmac239/RRV17577 #3 | 1792 | 188 | 2039 | 5859 | 1331 | MCD |
| 19490 | SIVmac239/RRV17577 #3 | 910 | 502 | 735 | 1449 | Alive | Lymphadenopathy |
| 21321 | SIVmac239/RRV17577 #3 | 2543 | 623 | 906 | 3092 | Alive | |
| 21491 | SIVmac239/RRV17577 #3 | 2196 | 1010 | 1760 | 4090 | 713 | Splenomegaly/lymphadenopathy |
| Cohort 4 | |||||||
| 19107 | SIVmac239/RRV17577 #7 | 1480 | 359 | 937 | 1793 | 680 | Lymphadenopathy |
| 19451 | SIVmac239/RRV17577 #7 | 592 | 99 | 308 | 1796 | 296 | Lymphadenopathy |
| 21520 | SIVmac239/RRV17577 #7 | 2525 | 598 | 1167 | 3870 | 887 | Splenomegaly |
| 21831 | SIVmac239/RRV17577 #7 | 2297 | 588 | 1665 | 2455 | 475 |
RF indicates retroperitoneal fibromatosis; and MCD, multicentric Castleman disease.