Baseline characteristics of investigated subjects
| . | Group 1: abnormal VWF multimers, n = 34 . | Group 2: normal VWF multimers and a mutation, n = 27 . | Group 3: normal VWF multimers and no mutation, n = 16 . | P* . |
|---|---|---|---|---|
| Male/female | 12/22 | 13/14 | 4/12 | .29 |
| Median age, y (range) | 40.5 (13-75) | 37 (6-67) | 27.5 (6-64) | .05 |
| Blood group O (%) | 18 (52.9) | 13 (48.1) | 13 (81.2) | .08 |
| Median VWF:RCo, IU/dL (IQ range) | 9.5 (15) | 52 (17) | 51.5 (20.5) | <.001 |
| Median VWF:Ag, IU/dL (IQ range) | 16 (18) | 52 (30) | 50 (24.5) | <.001 |
| Median FVIII:C, IU/dL (IQ range) | 24 (28) | 74 (46) | 70 (33) | <.001 |
| Mean VWF:RCo/VWF:Ag ratio (IQ range) | 0.67 (0.45) | 1.02 (0.28) | 1.06 (0.34) | .001 |
| Identified mutations, no. | ||||
| None | 3 | 0 | 16 | NA |
| One | 24 | 23 | 0 | NA |
| Two | 7† | 3 | 0 | NA |
| Three | 0 | 1 | 0 | NA |
| . | Group 1: abnormal VWF multimers, n = 34 . | Group 2: normal VWF multimers and a mutation, n = 27 . | Group 3: normal VWF multimers and no mutation, n = 16 . | P* . |
|---|---|---|---|---|
| Male/female | 12/22 | 13/14 | 4/12 | .29 |
| Median age, y (range) | 40.5 (13-75) | 37 (6-67) | 27.5 (6-64) | .05 |
| Blood group O (%) | 18 (52.9) | 13 (48.1) | 13 (81.2) | .08 |
| Median VWF:RCo, IU/dL (IQ range) | 9.5 (15) | 52 (17) | 51.5 (20.5) | <.001 |
| Median VWF:Ag, IU/dL (IQ range) | 16 (18) | 52 (30) | 50 (24.5) | <.001 |
| Median FVIII:C, IU/dL (IQ range) | 24 (28) | 74 (46) | 70 (33) | <.001 |
| Mean VWF:RCo/VWF:Ag ratio (IQ range) | 0.67 (0.45) | 1.02 (0.28) | 1.06 (0.34) | .001 |
| Identified mutations, no. | ||||
| None | 3 | 0 | 16 | NA |
| One | 24 | 23 | 0 | NA |
| Two | 7† | 3 | 0 | NA |
| Three | 0 | 1 | 0 | NA |